{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T10:34:27Z","timestamp":1789122867824,"version":"build-2803163510"},"reference-count":39,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:00:00Z","timestamp":1789084800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:00:00Z","timestamp":1789084800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Medical Radiation Sci"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>We report a pooled analysis of two multicentre intra\u2010patient randomised controlled trials (RCTs) comparing the silicone\u2010based dressings Mepitel Film and StrataXRT for the prevention of acute radiation dermatitis (ARD) in postmastectomy radiotherapy (RT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Each irradiated chest wall was divided into medial and lateral halves, randomised to one dressing each. The primary endpoint was the incidence of grade 2 or 3 ARD. Secondary endpoints included grade 3 ARD, moist desquamation, time to moist desquamation, Radiation\u2010Induced Skin Reaction Assessment Scale (RISRAS) scores, adverse events, and treatment preferences. Discordant\u2010pair methods, conditional logistic regression, paired comparisons of area under the curve (AUC), and longitudinal fixed\u2010effects regression were used.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 120 patients (median age, 60\u2009years; interquartile range, 51\u201369) were included (Australia,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200940; New Zealand,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200980); 64.2% received moderately hypofractionated or ultrahypofractionated RT. Among 38 discordant pairs, grade 2 or 3 ARD occurred only on the StrataXRT side in 30 patients and only on the Mepitel Film side in eight patients (odds ratio 3.75, 95% CI 1.72\u20138.18;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001). Grade 3 ARD and moist desquamation did not differ significantly. HCP\u2010assessed RISRAS AUCs for erythema (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and moist desquamation (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.034) were significantly lower with Mepitel Film, consistent with the longitudinal analyses. Patient\u2010reported RISRAS AUCs did not differ between treatments. Treatment preferences were broadly balanced.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Mepitel Film reduced the incidence of grade 2 or 3 ARD and cumulative HCP\u2010assessed erythema and moist desquamation burden compared with StrataXRT, while patient\u2010reported symptom burden was similar. Selection of a prophylactic dressing for postmastectomy RT should consider patient preference, cost, ease of application, skin sensitivity, and available resources.<\/jats:p>\n                    <jats:p>\n                      <jats:bold>Trial Registration:<\/jats:bold>\n                      Australian New Zealand Clinical Trials Registry: ACTRN12621000124831 and ACTRN12619001477112.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jmrs.70117","type":"journal-article","created":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T09:44:53Z","timestamp":1789119893000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>StrataXRT<\/scp>\n                    Versus Mepitel Film for Prevention of Acute Radiation Dermatitis in Postmastectomy Radiotherapy: A Pooled Analysis of Intra\u2010Patient Randomised Trials"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4696-9434","authenticated-orcid":false,"given":"Shing Fung","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology National University Cancer Institute, National University Hospital  Singapore Singapore"},{"name":"Department of Medicine, Yong Loo Lin School of Medicine National University of Singapore  Singapore Singapore"},{"name":"Department of Radiation Oncology, Olivia Newton\u2010John Cancer Wellness and Research Centre Austin Health  Heidelberg Victoria Australia"},{"name":"Department of Medical Imaging and Radiation Sciences, School of Primary and Allied Health Care, Faculty of Medicine, Nursing and Health Sciences Monash University  Clayton Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2173-2513","authenticated-orcid":false,"given":"Patries M.","family":"Herst","sequence":"additional","affiliation":[{"name":"Department of Radiation Therapy University of Otago  Wellington New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6123-1951","authenticated-orcid":false,"given":"Melissa L.","family":"James","sequence":"additional","affiliation":[{"name":"Canterbury Regional Cancer and Haematology Service Christchurch Hospital  Christchurch New Zealand"},{"name":"Department of Medicine, Christchurch Hospital University of Otago, Christchurch  Christchurch New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pui Lam","family":"Yip","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology National University Cancer Institute, National University Hospital  Singapore Singapore"},{"name":"Department of Medicine, Yong Loo Lin School of Medicine National University of Singapore  Singapore 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