{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T05:02:10Z","timestamp":1789794130861,"version":"4.0.1"},"reference-count":18,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T00:00:00Z","timestamp":1789689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T00:00:00Z","timestamp":1789689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Medical Radiation Sci"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>During radiation therapy, patients may experience positioning errors that can affect the irradiated volume and result in unnecessary radiation doses to normal tissues. Correcting for setup errors is essential for patients undergoing radiation therapy; however, it remains unclear whether six\u2010dimensional (6D) correction is superior to conventional three\u2010dimensional (3D) correction in nasopharyngeal cancer. Therefore, the purpose of this study was to compare the planning target volume (PTV) coverage between 3D and 6D cone\u2010beam computed tomography (CBCT) corrections for patients with nasopharyngeal carcinoma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively enrolled 30 patients with nasopharyngeal cancer who underwent image\u2010guided radiation therapy. The 3D and 6D corrections were performed using CBCT images registered to CT simulation images based on skeletal structures at 1, 3, and 5\u2009weeks, respectively. The volume percentages of the PTV achieving the prescribed dose of 70, 63, and 56\u2009Gy were calculated after both 3D and 6D corrections and were statistically compared using a repeated measures analysis of variance test.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The results showed that the percentage coverage of the target volume was 94.1%\u2009\u00b1\u20094.3% and 95.4%\u2009\u00b1\u20093.4% for 70\u2009Gy, 94.4%\u2009\u00b1\u20092.6% and 95.3%\u2009\u00b1\u20092.4% for 63\u2009Gy, and 92.1%\u2009\u00b1\u20097.7% and 95.6%\u2009\u00b1\u20095.4% for 56\u2009Gy after 3D and 6D corrections, respectively. A significant difference was noted in the volume coverage for 56\u2009Gy between the two correction methods. Additionally, the average maximum dose percentages after 3D and 6D corrections were 5.9%\u2009\u00b1\u20098.0% and 3.3%\u2009\u00b1\u20096.2% for the spinal cord, and 1.8%\u2009\u00b1\u20098.5% and 2.7%\u2009\u00b1\u20096.0% for the brain stem, respectively; however, no significant difference was observed between the two correction methods.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>We conclude that 6D correction for CBCT images achieved better dose coverage of the target tumour volume than 3D correction in patients with nasopharyngeal carcinoma.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jmrs.70126","type":"journal-article","created":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T04:21:43Z","timestamp":1789791703000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparison of Six\u2010 and Three\u2010Dimensional Error Corrections for the Planning Target Volume in Patients With Nasopharyngeal Cancer"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-2570-0480","authenticated-orcid":false,"given":"Huan\u2010Chun","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology Kaohsiung Municipal Ta\u2010Tung Hospital  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8488-2693","authenticated-orcid":false,"given":"Ming\u2010Chung","family":"Chou","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging and Radiological Sciences Kaohsiung Medical University  Kaohsiung Taiwan"},{"name":"Biomedical Artificial Intelligence Academy Kaohsiung Medical University  Kaohsiung Taiwan"},{"name":"Center for Big Data Research Kaohsiung Medical University  Kaohsiung Taiwan"},{"name":"Department of Medical Research Kaohsiung Medical University Hospital  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,18]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2016.01.040"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.30660"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.2196\/49968"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21834"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2020.12.007"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.2147\/CMAR.S341472"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2008.08.017"},{"issue":"3","key":"e_1_2_10_9_1","doi-asserted-by":"crossref","first-page":"S188","DOI":"10.1016\/j.ijrobp.2007.07.340","article-title":"Study of Rotational Setup Errors and Their Dosimetric Impacts on Head and Neck IMRT Treatments Using Kilovoltage Cone\u2010Beam Computed Tomography (kV CBCT)","volume":"69","author":"Fu W.","year":"2007","journal-title":"International Journal of Radiation Oncology, Biology, Physics"},{"issue":"1","key":"e_1_2_10_10_1","article-title":"Initial Experience With 6D Skull Tracking and Intrafractional Motion Monitoring in The United Arab Emirates' First CyberKnife(R) Radiosurgery Center","volume":"16","author":"Singh T.","year":"2024","journal-title":"Cureus"},{"key":"e_1_2_10_11_1","first-page":"48","article-title":"Six\u2010Dimensional Correction of Intra\u2010Fractional Prostate Motion With CyberKnife Stereotactic Body Radiation Therapy","volume":"1","author":"Lei S.","year":"2011","journal-title":"Frontiers in Oncology"},{"key":"e_1_2_10_12_1","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2022.1021119","article-title":"Quantifying 6D Tumor Motion and Calculating PTV Margins During Liver Stereotactic Radiotherapy With Fiducial Tracking","volume":"12","author":"Sun 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Margins for Glioblastoma Multiforme","volume":"14","author":"Pruthi D. S.","year":"2023","journal-title":"Journal of Neurosciences in Rural Practice"}],"container-title":["Journal of Medical Radiation Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmrs.70126","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jmrs.70126","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmrs.70126","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T04:21:45Z","timestamp":1789791705000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmrs.70126"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,18]]},"references-count":18,"alternative-id":["10.1002\/jmrs.70126"],"URL":"https:\/\/doi.org\/10.1002\/jmrs.70126","archive":["Portico"],"relation":{},"ISSN":["2051-3895","2051-3909"],"issn-type":[{"value":"2051-3895","type":"print"},{"value":"2051-3909","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,18]]},"assertion":[{"value":"2026-01-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"jmrs.70126"}}