{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T19:42:35Z","timestamp":1775072555107,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,2,12]],"date-time":"2024-02-12T00:00:00Z","timestamp":1707696000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Medical Radiation Sci"],"published-print":{"date-parts":[[2024,6]]},"abstract":"Abstract<\/jats:title>Introduction<\/jats:title>Differentiating malignant thyroid nodules from benign ones is challenging. Sonography is a non\u2010invasive modality that can be helpful in this regard and is far better than invasive methods like fine needle aspiration (FNA). This study aimed to assess the diagnostic value of colour Doppler ultrasonography in distinguishing malignant and benign nodules of thyroid gland.<\/jats:p><\/jats:sec>Methods<\/jats:title>The study involved patients with thyroiditis and thyroid nodules, who underwent sonography. Ultrasound findings were assessed. All the nodules were classified according to the FNA into malignant, follicular nodules and lymphatic. Then, sonography findings were compared between these three groups.<\/jats:p><\/jats:sec>Results<\/jats:title>There were 216 nodules, including 108 (50%) malignant nodules, 80 (37%) benign and 28 (13%) lymphatic follicles, were evaluated. Micro\u2010calcification was present in 50 (46.3%) malignant cases, 11 (13.7%) benign cases and 2 (2.1%) lymphatic follicles. Decreased or mixed vascularity was reported in 43 (69%) malignant nodules, 4 (5%) benign cases and 7 (25%) lymphatic follicles. Also, 9.7% and 42% of malignant and benign nodules had peripheral circular vascularity, respectively; however, none of the lymphatic follicles had this finding. With 89% specificity, 49% sensitivity and 73.5% accuracy, calcification with or without decreased or mixed vascularity could differentiate benign and malignant nodules.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Decreased or mixed vascularity with or without calcification shows high sensitivity in differentiating malignant and benign nodules.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmrs.751","type":"journal-article","created":{"date-parts":[[2024,2,12]],"date-time":"2024-02-12T10:05:19Z","timestamp":1707732319000},"page":"233-239","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Diagnostic value of colour Doppler ultrasound in differentiating malignant and benign nodules in thyroiditis background"],"prefix":"10.1002","volume":"71","author":[{"given":"Seyed Ali","family":"Alamdaran","sequence":"first","affiliation":[{"name":"Department of Radiology, Faculty of Medicine Mashhad University of Medical Sciences Mashhad Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melika","family":"Farshidianfar","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Islamic Azad University \u2013 Mashhad Branch Mashhad Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alireza","family":"Masoumi","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Islamic Azad University \u2013 Mashhad Branch Mashhad Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4594-9095","authenticated-orcid":false,"given":"Masoud Mahdavi","family":"Rashed","sequence":"additional","affiliation":[{"name":"Department of Radiology, Faculty of Medicine Mashhad University of Medical Sciences Mashhad Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masoumeh","family":"Jaberi","sequence":"additional","affiliation":[{"name":"Department of Radiology, Faculty of Medicine Mashhad University of Medical Sciences Mashhad Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,2,12]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.87.5.8504"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.5694\/mja17.01204"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/s20071822"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.7863\/jum.1994.13.2.87"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.7863\/jum.2004.23.11.1455"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/MLG.0b013e3181864ae7"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13244-015-0446-5"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03343959"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2373050220"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000096013"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.7863\/jum.2003.22.10.1027"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11547-007-0178-9"},{"key":"e_1_2_10_14_1","volume-title":"Endotext","author":"Majety P","year":"2000"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/0284185113498721"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.7863\/ultra.34.4.697"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.09.2459"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.46.1901"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2019.00003"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.09091284"},{"key":"e_1_2_10_21_1","first-page":"874","article-title":"Thyroid nodules: evaluation with power Doppler and duplex Doppler ultrasound. Otolaryngology\u2014Head and Neck","volume":"132","author":"Chammas MC","year":"2005","journal-title":"Surgery"},{"key":"e_1_2_10_22_1","unstructured":"CarolMR.Diagnostic ultrasound\/Carol M. Rumack.2018."},{"key":"e_1_2_10_23_1","first-page":"759","article-title":"Diagnostic performance of gray\u2010scale versus combined gray\u2010scale with colour doppler ultrasonography in the diagnosis of malignancy in thyroid nodules","volume":"10","author":"Phuttharak W","year":"2009","journal-title":"Asian Pac J Cancer Prev"},{"key":"e_1_2_10_24_1","first-page":"147","article-title":"Gray\u2010scale vs. color Doppler ultrasound in cold thyroid nodules","volume":"7","author":"Salehi M","year":"2015","journal-title":"Global J Health Sci"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/RUQ.0000000000000228"}],"container-title":["Journal of Medical Radiation Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmrs.751","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T10:00:05Z","timestamp":1718359205000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmrs.751"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,12]]},"references-count":24,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["10.1002\/jmrs.751"],"URL":"https:\/\/doi.org\/10.1002\/jmrs.751","archive":["Portico"],"relation":{},"ISSN":["2051-3895","2051-3909"],"issn-type":[{"value":"2051-3895","type":"print"},{"value":"2051-3909","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,12]]},"assertion":[{"value":"2023-01-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}