{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T03:34:53Z","timestamp":1784604893000,"version":"3.55.0"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,2,12]],"date-time":"2015-02-12T00:00:00Z","timestamp":1423699200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001027","name":"Australian Government Department of Health and Ageing","doi-asserted-by":"crossref","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}],"id":[{"id":"10.13039\/501100001027","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Medical Radiation Sci"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Intensity modulated radiotherapy (<jats:styled-content style=\"fixed-case\">IMRT<\/jats:styled-content>) is ideal for anal canal cancer (<jats:styled-content style=\"fixed-case\">ACC<\/jats:styled-content>), delivering high doses to irregular tumour volumes whilst minimising dose to surrounding normal tissues. Establishing achievable dose objectives is a challenge. The purpose of this paper was to utilise data collected in the Assessment of New Radiation Oncology Treatments and Technologies (<jats:styled-content style=\"fixed-case\">ANROTAT<\/jats:styled-content>) project to evaluate the feasibility of <jats:styled-content style=\"fixed-case\">ACC IMRT<\/jats:styled-content> dose planning objectives employed in the Australian situation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Ten Australian centres were randomly allocated three data sets from 15 non\u2010identifiable computed tomography data sets representing a range of disease stages and gender. Each data set was planned by two different centres, producing 30 plans. All tumour and organ at risk (<jats:styled-content style=\"fixed-case\">OAR<\/jats:styled-content>) contours, prescription and dose constraint details were provided. Dose\u2013volume histograms (<jats:styled-content style=\"fixed-case\">DVH<\/jats:styled-content>s) for each plan were analysed to evaluate the feasibility of dose planning objectives provided.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All dose planning objectives for the bone marrow (BM) and femoral heads were achieved. Median planned doses exceeded one or more objectives for bowel, external genitalia and bladder. This reached statistical significance for bowel V30 (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.04), V45 (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), V50 (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), external genitalia V20 (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) and bladder V35 (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), V40 (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.01). Gender was found to be the only significant factor in the likelihood of achieving the bowel V50 (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.03) and BM V30 constraints (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.04).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The dose planning objectives used in the <jats:styled-content style=\"fixed-case\">ANROTAT<\/jats:styled-content> project provide a good starting point for <jats:styled-content style=\"fixed-case\">ACC IMRT<\/jats:styled-content> planning. To facilitate clinical implementation, it is important to prioritise <jats:styled-content style=\"fixed-case\">OAR<\/jats:styled-content> objectives and recognise factors that affect the achievability of these objectives.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmrs.99","type":"journal-article","created":{"date-parts":[[2015,2,13]],"date-time":"2015-02-13T10:16:46Z","timestamp":1423822606000},"page":"99-107","source":"Crossref","is-referenced-by-count":6,"title":["Dose planning objectives in anal canal cancer <scp>IMRT<\/scp>: the <scp>TROG ANROTAT<\/scp> experience"],"prefix":"10.1002","volume":"62","author":[{"given":"Elizabeth","family":"Brown","sequence":"first","affiliation":[{"name":"Princess Alexandra Hospital Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison","family":"Cray","sequence":"additional","affiliation":[{"name":"Peter MacCallum Cancer Cancer Centre Box Hill Victoria 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