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Mass Spectrom."],"published-print":{"date-parts":[[2006,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>When zotepine, an antipsychotic drug, was electrochemically oxidized using electrospray ionization mass spectrometry (ESI\u2010MS) coupled with a microflow electrolytic cell, [M + 16 + H]<jats:sup>+<\/jats:sup> (<jats:italic>m<\/jats:italic>\/<jats:italic>z<\/jats:italic> 348), [M\u2014H]<jats:sup>+<\/jats:sup> (<jats:italic>m<\/jats:italic>\/<jats:italic>z<\/jats:italic> 330) and [M\u201414 + H]<jats:sup>+<\/jats:sup> (<jats:italic>m<\/jats:italic>\/<jats:italic>z<\/jats:italic> 318) were observed as electrochemical oxidation product ions (M represents the zotepine molecule). Although a major fragment ion that was derived from the dimethyl aminoethyl moiety was observed only at <jats:italic>m<\/jats:italic>\/<jats:italic>z<\/jats:italic> 72 in the collision\u2010induced dissociation (CID) spectrum of zotepine, new fragments such as <jats:italic>m<\/jats:italic>\/<jats:italic>z<\/jats:italic> 315 and 286 ions could be generated in the CID spectrum by combining electrochemical oxidation and CID. Since these fragments were relatively specific with high ion strength, it was thought that they would be useful for developing a sensitive LC\u2010MS\/MS assay. The S\u2010oxide and <jats:italic>N<\/jats:italic>\u2010demethylated products were detected by electrolysis assuring that a portion of P450 metabolites of zotepine could be mimicked by the electrochemistry\/electrospray ionization mass spectrometry (EC\/ESI\u2010MS) system. Copyright \u00a9 2006 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/jms.1017","type":"journal-article","created":{"date-parts":[[2006,3,30]],"date-time":"2006-03-30T08:46:39Z","timestamp":1143708399000},"page":"606-612","source":"Crossref","is-referenced-by-count":19,"title":["Investigation of the electrochemical oxidation products of zotepine and their fragmentation using on\u2010line electrochemistry\/electrospray ionization mass spectrometry"],"prefix":"10.1002","volume":"41","author":[{"given":"Kazuyoshi","family":"Nozaki","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Kitagawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sumihisa","family":"Kimura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Kagayama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryuichi","family":"Arakawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,3,30]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"1588","article-title":"Pharmacological study of [2\u2010chloro\u201011\u2010(2\u2010dimethylaminoethoxy) dibenzo[b,f]thiepine] (zotepine), a new neuroleptic drug","volume":"29","author":"Uchida S","year":"1979","journal-title":"Arzneimittel\u2010Forschung"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.2174\/0929867043456089"},{"key":"e_1_2_6_4_2","first-page":"1595","article-title":"Pharmacokinetics and metabolism of 2\u2010chloro\u201011\u2010(2\u2010dimethylaminoethoxy)\u2010dibenzo[b,f]thiepine (zotepine) in rat, mouse, dog and man","volume":"29","author":"Noda K","year":"1979","journal-title":"Arzneimittel\u2010Forschung."},{"key":"e_1_2_6_5_2","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/0731-7085(95)01637-6","article-title":"A capillary gas\u2010liquid chromatographic method for the assay of the neuroleptic drug zotepine in human serum or plasma","volume":"14","author":"Urlrich S","year":"1996","journal-title":"J. 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