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In this work, electrospray ionization\u2010mass spectrometry(ESI\u2010MS) was used to identify the gamma radiation\u2010induced covalent cross\u2010linking of model peptides (sequence YPPW and pYPPW) with the nucleobase thymine. Tandem electrospray ionization\u2010mass spectrometry (ESI\u2010MS<jats:sup><jats:italic>n<\/jats:italic><\/jats:sup>) was employed to investigate the cross\u2010linking sites. The results showed that irrespective of whether tyrosine was phosphorylated or not, the nucleobase thymine was cross\u2010linked with the tryptophan residue. Possible cross\u2010linking mechanisms are proposed by investigating the related mass peaks. Copyright \u00a9 2006 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/jms.1090","type":"journal-article","created":{"date-parts":[[2006,8,21]],"date-time":"2006-08-21T10:17:17Z","timestamp":1156155437000},"page":"1205-1211","source":"Crossref","is-referenced-by-count":4,"title":["Identification of radiation\u2010induced cross\u2010linking between thymine and tryptophan by electrospray ionization\u2010mass spectrometry"],"prefix":"10.1002","volume":"41","author":[{"given":"Wei\u2010Qun","family":"Shi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao\u2010Yang","family":"Su","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Cai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu\u2010Fen","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan\u2010Mei","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,8,21]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.6.2557"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.17.7915"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00207507"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.77.4.1763"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0027-5107(94)90245-3"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.274.5284.99"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.cb.10.110194.002105"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/scientificamerican0197-52"},{"key":"e_1_2_6_10_2","doi-asserted-by":"crossref","first-page":"43","DOI":"10.2307\/3579234","article-title":"The effect of dimethyl\u2010sulfoxide on the induction of DNA double\u2010strand breaks in v79\u20104 mammalian\u2010cells by alpha\u2010particles","volume":"144","author":"de Lara CM","year":"1995","journal-title":"Radiat. 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