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In this work, we have analyzed new aromatic HMBPs and their prodrugs with electrospray tandem mass spectrometry (ESI\u2010MS<jats:sup><jats:italic>n<\/jats:italic><\/jats:sup>). We describe, for the first time, a complete study of fragmentation patterns, in both positive and negative\u2010ion modes. In positive mode, the cation dissociations are mainly elimination of water and phosphorus fragments. In negative mode, losses of ROH (R\uf8feH, C<jats:sub>6<\/jats:sub>H<jats:sub>5<\/jats:sub>, CH<jats:sub>3<\/jats:sub>OC<jats:sub>6<\/jats:sub>H<jats:sub>5<\/jats:sub>) and HPO<jats:sub>2<\/jats:sub> were observed. The results have revealed specific structural fingerprints for the screening of these compounds in complex biological mixtures. Copyright \u00a9 2008 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/jms.1379","type":"journal-article","created":{"date-parts":[[2008,2,20]],"date-time":"2008-02-20T06:49:40Z","timestamp":1203490180000},"page":"1037-1044","source":"Crossref","is-referenced-by-count":9,"title":["Fragmentation patterns of new esterified and unesterified aromatic 1\u2010hydroxymethylene\u20101, 1\u2010bisphosphonic acids by ESI\u2010MS<sup><i>n<\/i><\/sup>"],"prefix":"10.1002","volume":"43","author":[{"given":"Julie","family":"Hardouin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erwann","family":"Gu\u00e9nin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ma\u00eblle","family":"Monteil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel","family":"Caron","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"Lecouvey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,2,20]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm020819i"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0162-0134(01)00412-3"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.2174\/0929867033368529"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1186\/bcr414"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jorganchem.2004.09.069"},{"key":"e_1_2_6_7_2","first-page":"6538","article-title":"Bisphosphonates 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