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The development of a fast and simple screening technique for the simultaneous determination of various volatiles is of great importance, because of their widespread use, frequent occurrence in forensic toxicological questions and the fact that there is often no hint on involved substances at the crime scene. To simulate a screening procedure, eight VOC with different chemical characteristics were chosen (isoflurane, halothane, hexane, chloroform, benzene, isooctane, toluene and xylene). To achieve maximum sensitivity, variables that influence the SPME process, such as type of fiber, extraction and desorption temperature and time, agitation and additives were optimized by preliminary studies and by means of a central composite design. The limits of detection and recoveries ranged from 2.9 \u00b5g\/l (xylene) to 37.1 \u00b5g\/l (isoflurane) and 7.9% (chloroform) to 61.5% (benzene), respectively. This procedure can be used to answer various forensic and toxicological questions. The short time taken for the whole analytical procedure may make its eventual adoption for routine analysis attractive. Copyright \u00a9 2010 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/jms.1723","type":"journal-article","created":{"date-parts":[[2010,3,20]],"date-time":"2010-03-20T11:36:37Z","timestamp":1269084997000},"page":"391-397","source":"Crossref","is-referenced-by-count":20,"title":["Qualitative screening for volatile organic compounds in human blood using solid\u2010phase microextraction and gas chromatography\u2010mass spectrometry"],"prefix":"10.1002","volume":"45","author":[{"given":"Anne Kathrin","family":"Gottzein","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Musshoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Burkhard","family":"Madea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,3,18]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.2175\/106143007X175988"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2004.01.046"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(01)00953-0"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2009.05.022"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2003.09.007"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2004.05.015"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1515\/CCLM.2009.133"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2004.03.001"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1021\/ac025984k"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4347(01)00518-7"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2008.08.014"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2008.07.064"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2009.06.067"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4347(99)00349-7"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0379-0738(02)00182-2"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/jat\/24.5.372"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1520\/JFS14754J"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1520\/JFS15073J"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.paf.0000188167.70732.9d"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.paf.0000188076.54147.07"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4347(00)00364-9"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.forsciint.2008.12.022"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1021\/ac00218a019"},{"key":"e_1_2_5_25_2","volume-title":"Solid Phase Microextraction: Theory and Practice","author":"Pawliszyn. 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