{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T13:46:36Z","timestamp":1775483196775,"version":"3.50.1"},"reference-count":47,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,1,26]],"date-time":"2012-01-26T00:00:00Z","timestamp":1327536000000},"content-version":"vor","delay-in-days":25,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Mass. Spectrom."],"published-print":{"date-parts":[[2012,1]]},"abstract":"<jats:p>Since 2004, a number of herbal blends containing different synthetic compounds mimicking the pharmacological activity of cannabinoids and displaying a high toxicological potential have appeared in the market. Their availability is mainly based on the so\u2010called \u201ce\u2010commerce\u201d, being sold as legal alternatives to cannabis and cannabis derivatives. Although highly selective, sensitive, accurate, and quantitative methods based on GC\u2013MS and LC\u2013MS are available, they lack simplicity, rapidity, versatility and throughput, which are required for product monitoring. In this context, matrix\u2010assisted laser desorption ionization\u2010time of flight mass spectrometry (MALDI\u2010TOF MS) offers a simple and rapid operation with high throughput. Thus, the aim of the present work was to develop a MALDI\u2010TOF MS method for the rapid qualitative direct analysis of herbal blend preparations for synthetic cannabinoids to be used as front screening of confiscated clandestine preparations. The sample preparation was limited to herbal blend leaves finely grinding in a mortar and loading onto the MALDI plate followed by addition of 2 \u00b5l of the matrix\/surfactant mixture [\u03b1\u2010cyano\u20104\u2010hydroxy\u2010cinnamic acid\/cetyltrimethylammonium bromide (CTAB)]. After drying, the sample plate was introduced into the ion source for analysis. MALDI\u2010TOF conditions were as follows: mass spectra were analyzed in the range <jats:italic>m\/z<\/jats:italic> 150\u2013550 by averaging the data from 50 laser shots and using an accelerating voltage of 20\u2009kV.<\/jats:p><jats:p>The described method was successfully applied to the screening of 31 commercial herbal blends, previously analyzed by GC\u2013MS. Among the samples analyzed, 21 contained synthetic cannabinoids (namely JWH\u2010018, JWH\u2010073, JWH\u2010081, JWH\u2010250, JWH\u2010210, JWH\u2010019, and AM\u2010694).<\/jats:p><jats:p>All the results were in agreement with GC\u2013MS, which was used as the reference technique. Copyright \u00a9 2012 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/jms.2036","type":"journal-article","created":{"date-parts":[[2012,1,26]],"date-time":"2012-01-26T08:51:33Z","timestamp":1327567893000},"page":"141-146","source":"Crossref","is-referenced-by-count":41,"title":["Direct screening of herbal blends for new synthetic cannabinoids by MALDI\u2010TOF MS"],"prefix":"10.1002","volume":"47","author":[{"given":"Rossella","family":"Gottardo","sequence":"first","affiliation":[{"name":"Department of Public Health and Community Medicine, Unit of Forensic Medicine University of Verona p.le Scuro, 10  Policlinico 37134 Verona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Chiarini","sequence":"additional","affiliation":[{"name":"Department of Life and Reproduction Science, Histology and Embryology Section University of Verona Strada le grazie  837134 Verona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilaria","family":"Dal Pr\u00e0","sequence":"additional","affiliation":[{"name":"Department of Life and Reproduction Science, Histology and Embryology Section University of Verona Strada le grazie  837134 Verona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catia","family":"Seri","sequence":"additional","affiliation":[{"name":"National Early Warning System Department of Anti\u2010Drug Policies, Presidency of the Council of Ministers, Coordination Centre, via Germania  20\u201037136 Verona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Rimondo","sequence":"additional","affiliation":[{"name":"National Early Warning System Department of Anti\u2010Drug Policies, Presidency of the Council of Ministers, Coordination Centre, via Germania  20\u201037136 Verona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Serpelloni","sequence":"additional","affiliation":[{"name":"Department of Anti\u2010Drug Policies Presidency of the Council of Ministers via Po  16\/A\u201000198 Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ubaldo","family":"Armato","sequence":"additional","affiliation":[{"name":"Department of Life and Reproduction Science, Histology and Embryology Section University of Verona Strada le grazie  837134 Verona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franco","family":"Tagliaro","sequence":"additional","affiliation":[{"name":"Department of Public Health and Community Medicine, Unit of Forensic Medicine University of Verona p.le Scuro, 10  Policlinico 37134 Verona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,1,26]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.57.439"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/jms.1558"},{"key":"e_1_2_6_4_1","unstructured":"European Monitoring Centre for Drugs and Drug Addiction (EMCDDA). 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