{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T18:02:48Z","timestamp":1790100168256,"version":"4.0.1"},"reference-count":38,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2014,10,22]],"date-time":"2014-10-22T00:00:00Z","timestamp":1413936000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Coordena\u00ef\u00bf\u00bd\u00ef\u00bf\u00bdo de Aperfei\u00ef\u00bf\u00bdoamento de Pessoal de N\u00ef\u00bf\u00bdvel Superior - CAPES"},{"name":"Funda\u00ef\u00bf\u00bd\u00ef\u00bf\u00bdo de Amparo \u00ef\u00bf\u00bd Pesquisa do Estado de S\u00ef\u00bf\u00bdo Paulo - FAPESP","award":["2009\/51145-3"],"award-info":[{"award-number":["2009\/51145-3"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Mass Spectrom."],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:p>Actinomycetes, especially those belonging to the genus <jats:italic>Streptomyces<\/jats:italic>, are economically important from a biotechnological standpoint: they produce antibiotics, anticancer compounds and a variety of bioactive substances that are potentially applicable in the agrochemical and pharmaceutical industries. This paper combined accurate\u2010mass electrospray tandem mass spectrometry in the full scan and product ion scan modes with compounds library data to identify the major compounds in the crude extract produced by <jats:italic>Streptomyces<\/jats:italic> sp. AMC 23; it also investigated how sodiated nonactin ([M\u2009+\u2009Na]<jats:sup>+<\/jats:sup>) fragmented. Most product ions resulted from elimination of 184 mass units due to consecutive McLafferty\u2010type rearrangements. The data allowed identification of four macrotetrolides homologous to nonactin (monactin, isodinactin, isotrinactin\/trinactin and tetranactin) as well as three related linear dimer compounds (nonactyl nonactoate, nonactyl homononactoate and homononactyl homononactoate). The major product ions of the sodiated molecules of these compounds also originated from elimination of 184 and 198 mass units. UPLC\u2010MS\/MS in the neutral loss scan mode helped to identify these compounds on the basis of the elimination of 184 and 198 mass units. This method aided monitoring of the relative production of these compounds for 32\u2009days and revealed that the biosynthetic process began with increased production of linear dimers as compared with macrotetrolides. These data could facilitate dereplication and identification of these compounds in other microbial crude extracts. Copyright \u00a9 2014 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/jms.3432","type":"journal-article","created":{"date-parts":[[2014,10,29]],"date-time":"2014-10-29T06:17:11Z","timestamp":1414563431000},"page":"1117-1126","source":"Crossref","is-referenced-by-count":19,"title":["Dereplication of <i>Streptomyces<\/i> sp. AMC 23 polyether ionophore antibiotics by accurate\u2010mass electrospray tandem mass spectrometry"],"prefix":"10.1002","volume":"49","author":[{"given":"Eduardo J.","family":"Crevelin","sequence":"first","affiliation":[{"name":"Departamento de Qu\u00edmica, Faculdade de Filosofia, Ci\u00eancias e Letras de Ribeir\u00e3o Preto Universidade de S\u00e3o Paulo\u2014USP  Ribeir\u00e3o Preto SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ant\u00f4nio E. M.","family":"Crotti","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica, Faculdade de Filosofia, Ci\u00eancias e Letras de Ribeir\u00e3o Preto Universidade de S\u00e3o Paulo\u2014USP  Ribeir\u00e3o Preto SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiago D.","family":"Zucchi","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Microbiologia Ambiental Empresa Brasileira de Pesquisas Agropecu\u00e1ria (Embrapa)  Jaguari\u00fana SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Itamar S.","family":"Melo","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Microbiologia Ambiental Empresa Brasileira de Pesquisas Agropecu\u00e1ria (Embrapa)  Jaguari\u00fana SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiz A. B.","family":"Moraes","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica, Faculdade de Filosofia, Ci\u00eancias e Letras de Ribeir\u00e3o Preto Universidade de S\u00e3o Paulo\u2014USP  Ribeir\u00e3o Preto SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,10,22]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00253-012-4681-0"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/jobm.201100500"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2672.2008.03940.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00253-013-5229-7"},{"key":"e_1_2_6_6_1","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1007\/s10482-013-9901-9","article-title":"Streptomyces araujoniae sp nov.: an actinomycete isolated from a potato tubercle","volume":"103","author":"Silva L. 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