{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T10:33:29Z","timestamp":1790332409392,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,3,4]],"date-time":"2016-03-04T00:00:00Z","timestamp":1457049600000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Mass Spectrom."],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:p>Identification of degradation products from trace organic compounds, which may retain the biological activity of the parent compound, is an important step in understanding the long\u2010term effects of these compounds on the environment. Constructed wetlands have been successfully utilized to remove contaminants from wastewater effluent, including pharmacologically active compounds. However, relatively little is known about the transformation products formed during wetland treatment. In this study, three different wetland microcosm treatments were used to determine the biotransformation products of the \u03b2\u2010adrenoreceptor antagonists atenolol, metoprolol and propranolol. LC\/ESI\u2010Q\u2010ToF run in the MS<jats:sup>E<\/jats:sup> and MS\/MS modes was used to identify and characterize the degradation products through the accurate masses of precursor and product ions. The results were compared with those of a reference standard when available. Several compounds not previously described as biotransformation products produced in wetlands were identified, including propranolol\u2010O\u2010sulfate, 1\u2010naphthol and the human metabolite <jats:italic>N<\/jats:italic>\u2010deaminated metoprolol. Transformation pathways were significantly affected by microcosm conditions and differed between compounds, despite the compounds' structural similarities. Altogether, a diverse range of transformation products in wetland microcosms were identified and elucidated using high resolving MS. This work shows that transformation products are not always easily predicted, nor formed via the same pathways even for structurally similar compounds. Copyright \u00a9 2016 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/jms.3737","type":"journal-article","created":{"date-parts":[[2016,3,8]],"date-time":"2016-03-08T23:36:42Z","timestamp":1457480202000},"page":"207-218","source":"Crossref","is-referenced-by-count":13,"title":["Identification of transformation products from \u03b2\u2010blocking agents formed in wetland microcosms using LC\u2010Q\u2010ToF"],"prefix":"10.1002","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1889-0668","authenticated-orcid":false,"given":"Alfred","family":"Svan","sequence":"first","affiliation":[{"name":"Division of Analytical Pharmaceutical Chemistry Uppsala University  BMC Box 574 SE\u2010751 23 Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikael","family":"Hedeland","sequence":"additional","affiliation":[{"name":"Division of Analytical Pharmaceutical Chemistry Uppsala University  BMC Box 574 SE\u2010751 23 Uppsala Sweden"},{"name":"National Veterinary Institute (SVA), Department of Chemistry Environment and Feed Hygiene  SE\u2010751 89 Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torbj\u00f6rn","family":"Arvidsson","sequence":"additional","affiliation":[{"name":"Division of Analytical Pharmaceutical Chemistry Uppsala University  BMC Box 574 SE\u2010751 23 Uppsala Sweden"},{"name":"Medical Products Agency  Box 26 SE\u2010751 03 Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin T.","family":"Jasper","sequence":"additional","affiliation":[{"name":"Department of Civil and Environmental Engineering University of California at Berkeley  Berkeley CA 94720 United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David L.","family":"Sedlak","sequence":"additional","affiliation":[{"name":"Department of Civil and Environmental Engineering University of California at Berkeley  Berkeley CA 94720 United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Curt E.","family":"Pettersson","sequence":"additional","affiliation":[{"name":"Division of Analytical Pharmaceutical Chemistry Uppsala University  BMC Box 574 SE\u2010751 23 Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,3,4]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/es1030799"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1897\/09-173.1"},{"key":"e_1_2_5_4_1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.jpba.2014.12.019","article-title":"Detection and quantification of residues and metabolites of medicinal products in environmental compartments, food commodities and workplaces: a review","volume":"106","author":"Bottoni P.","year":"2014","journal-title":"J. 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