{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:33:33Z","timestamp":1777422813830,"version":"3.51.4"},"reference-count":31,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2016,11,7]],"date-time":"2016-11-07T00:00:00Z","timestamp":1478476800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81460232"],"award-info":[{"award-number":["81460232"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Mass Spectrom."],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:p>Newborn screening is one of public health concerns designed to screen infants shortly after birth. Prenatal exposure to tobacco smoke such as nicotine has been reported to affect babies. Levels of nicotine and cotinine in meconium were widely used to evaluate the tobacco exposure of foetuses during pregnancy in a polluted environment. In this study, medical swabs were applied by using touch spray\u2010mass spectrometry (TS\u2010MS) to collect meconium from newborn infants for detection of nicotine and cotinine. Parameters such as choice of spray solvents, solvent volume and collision energy for screening of nicotine and cotinine were optimized. The limits of detection, reproducibility and matrix effect for analysis of meconium were also investigated. In this study, the levels of nicotine and cotinine in 54 puerpera volunteers were screened by TS\u2010MS and were validated by using traditional liquid chromatography\u2010mass spectrometry. These results showed that medical swab TS\u2010MS would be useful for newborn screening of nicotine and cotinine in meconium with high reproducibility, speed, sensitivity and specificity. The use of disposable medical swabs involves no sample preparation and no chromatographic separation, significantly reducing the cost and time required for screening a large number of clinical sample. Copyright \u00a9 2016 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/jms.3892","type":"journal-article","created":{"date-parts":[[2016,10,13]],"date-time":"2016-10-13T05:18:47Z","timestamp":1476335927000},"page":"1237-1242","source":"Crossref","is-referenced-by-count":17,"title":["Medical swab touch spray\u2010mass spectrometry for newborn screening of nicotine and cotinine in meconium"],"prefix":"10.1002","volume":"51","author":[{"given":"Bi\u2010cheng","family":"Yang","sequence":"first","affiliation":[{"name":"Jiangxi Provincial Maternal and Child Health Hospital  Nanchang Jiangxi 330006 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Wang","sequence":"additional","affiliation":[{"name":"Jiangxi Provincial Maternal and Child Health Hospital  Nanchang Jiangxi 330006 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao","family":"Yang","sequence":"additional","affiliation":[{"name":"Jiangxi Provincial Maternal and Child Health Hospital  Nanchang Jiangxi 330006 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Zou","sequence":"additional","affiliation":[{"name":"Jiangxi Provincial Maternal and Child Health Hospital  Nanchang Jiangxi 330006 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia\u2010chun","family":"Wang","sequence":"additional","affiliation":[{"name":"Jiangxi Provincial Maternal and Child Health Hospital  Nanchang Jiangxi 330006 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Zou","sequence":"additional","affiliation":[{"name":"Jiangxi Provincial Maternal and Child Health Hospital  Nanchang Jiangxi 330006 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fa\u2010ying","family":"Liu","sequence":"additional","affiliation":[{"name":"Jiangxi Provincial Maternal and Child Health Hospital  Nanchang Jiangxi 330006 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huai","family":"Liu","sequence":"additional","affiliation":[{"name":"Jiangxi Provincial Maternal and Child Health Hospital  Nanchang Jiangxi 330006 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ou\u2010ping","family":"Huang","sequence":"additional","affiliation":[{"name":"Jiangxi Provincial Maternal and Child Health Hospital  Nanchang Jiangxi 330006 China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,11,7]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2004.01.010"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00008480-199504000-00002"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0146-0005(96)80079-6"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2008.109173"},{"key":"e_1_2_5_6_1","doi-asserted-by":"crossref","first-page":"7785","DOI":"10.1007\/s00216-014-8243-4","article-title":"Development of a multi\u2010residue method in a fetal matrix: analysis of meconium","volume":"406","author":"Meyer\u2010Monath M.","year":"2014","journal-title":"Anal Bioanal Chem"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2015.04.008"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/jat\/bkt092"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2011.337"},{"key":"e_1_2_5_10_1","article-title":"Ambient ionization mass spectrometry for point\u2010of\u2010care diagnostics and other clinical measurements","author":"Ferreira C. 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