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Mass Spectrom."],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:p>An Open Probe inlet was combined with a low thermal mass ultra\u2010fast gas chromatograph (GC), in\u2010vacuum electron ionization ion source and a mass spectrometer (MS) of GC\u2013MS for obtaining real\u2010time analysis with separation. The Open Probe enables ambient sampling via sample vaporization in an oven that is open to room air, and the ultra\u2010fast GC provides ~30\u2010s separation, while if no separation is required, it can act as a transfer line with 2 to 3\u2010s sample transfer time. Sample analysis is as simple as touching the sample, pushing the sample holder into the Open Probe oven and obtaining the results in 30\u00a0s. The Open Probe fast GC was mounted on a standard Agilent 7890 GC that was coupled with an Agilent 5977A MS. Open Probe fast GC\u2013MS provides real\u2010time analysis combined with GC separation and library identification, and it uses the low\u2010cost MS of GC\u2013MS. The operation of Open Probe fast GC\u2013MS is demonstrated in the 30\u2010s separation and 50\u2010s full analysis cycle time of tetrahydrocannabinol and cannabinol in Cannabis flower, sub 1\u2010min analysis of trace trinitrotoluene transferred from a finger onto a glass surface, vitamin E in canola oil, sterols in olive oil, polybrominated flame retardants in plastics, alprazolam in Xanax drug pill and free fatty acids and cholesterol in human blood. The extrapolated limit of detection for pyrene is &lt;1\u00a0fg, but the concentration is too high and the software noise calculation is untrustworthy. The broad range of compounds amenable for analysis is demonstrated in the analysis of reserpine. The possible use with alternate standard GC\u2013MS and Open Probe fast GC\u2013MS is demonstrated in the analysis of heroin in its street drug powder. The use of Open Probe with the fast GC acting as a transfer line is demonstrated in &lt;10\u2010s analysis without separation of ibuprofen and estradiol. Copyright \u00a9 2017 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/jms.3941","type":"journal-article","created":{"date-parts":[[2017,4,28]],"date-time":"2017-04-28T22:48:36Z","timestamp":1493419716000},"page":"417-426","source":"Crossref","is-referenced-by-count":19,"title":["Open Probe fast GC\u2013MS \u2014 combining ambient sampling ultra\u2010fast separation and in\u2010vacuum ionization for real\u2010time analysis"],"prefix":"10.1002","volume":"52","author":[{"given":"U.","family":"Keshet","sequence":"first","affiliation":[{"name":"School of Chemistry Tel Aviv University  Tel Aviv 69978 Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Alon","sequence":"additional","affiliation":[{"name":"School of Chemistry Tel Aviv University  Tel Aviv 69978 Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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