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Mass Spectrom."],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:p>The purpose of this study was to investigate the effect of radiation on the content of animal diet constituents using global metabolomics. Aqueous methanolic extracts of control and cobalt\u201060\u2010irradiated Teklad 7001 diets were comprehensively analyzed using nano\u2010liquid chromatography\u2013MS\/MS. Among the over 2000 ions revealed by XCMS followed by data preprocessing, 94 positive and 143 negative metabolite ions had greater than 1.5\u2010fold changes and <jats:italic>p<\/jats:italic>\u2010values &lt;0.01. Use of <jats:sc>MetaboAnalyst<\/jats:sc> statistical software demonstrated complete separation of the irradiated and non\u2010radiated diets in unsupervised principal components analysis and supervised partial least squares discriminant analysis. Irradiation led to an increase in the content of phytochemicals such as glucosinolates and oxidized lipids in the diet. Twenty\u2010eight metabolites that were significantly changed in the irradiated samples were putatively identified at the level of molecular formulae by MS\/MS. MS\/MS<jats:sup>ALL<\/jats:sup> analysis of chloroform\u2013methanol extracts of the irradiated diet showed increased levels of a number of unique linoleic acid\u2010derived branched fatty acid esters of hydroxy fatty acids. These data imply that gamma irradiation of animal diets causes chemical changes to dietary components, which in turn may influence the risk of mammary cancer. 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