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The aim of this study was to profile and compare the proteome of placentas from healthy pregnant women and those with GDM, to investigate the placenta\u2010specific protein composition and possible changes of its function in presence of GDM. Quantitative proteomic analysis, based on LC\u2010MS<jats:sup>E<\/jats:sup> approach, revealed that higher (approximately 15% increase) levels of galectin 1 and collagen alpha\u20101 XIV chain (although the difference regarding the latter was at the limit of significance) were present in GDM samples, while heat shock 70\u00a0kDa protein 1A\/1B was less abundant in GDM placental tissue. These data seem to indicate that GDM, when well controlled, did not markedly affect the placental proteome.<\/jats:p>","DOI":"10.1002\/jms.4336","type":"journal-article","created":{"date-parts":[[2019,1,24]],"date-time":"2019-01-24T15:54:20Z","timestamp":1548345260000},"page":"359-365","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Is the placental proteome impaired in well\u2010controlled gestational diabetes?"],"prefix":"10.1002","volume":"54","author":[{"given":"Silvia","family":"Burlina","sequence":"first","affiliation":[{"name":"Department of Medicine \u2013 DIMED University of Padova  Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Banfi","sequence":"additional","affiliation":[{"name":"Centro Cardiologico Monzino IRCCS  Milan 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