{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T10:28:26Z","timestamp":1777026506592,"version":"3.51.4"},"reference-count":30,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,11,8]],"date-time":"2019-11-08T00:00:00Z","timestamp":1573171200000},"content-version":"vor","delay-in-days":38,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Mass Spectrom"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Recently in Canada and some states of the United States, marijuana (cannabis) has become fully legalized and regulated, for both medical and recreational purposes. This fact is going to make cannabis products such as edibles even more popular than ever before. Therefore, it is assumed that there will be a high demand for analytical methods, which are accurate and sensitive enough to be used in different forensic and pharmaceutical cannabis\u2013related applications. Cannabis derivatives have an extreme range and number of constituents with possible interactions with one another. Thus, this characteristic leads to their vast and highly complex chemistry, which requires robust analytical tools to be able to precisely and accurately quantify and qualify them. We developed and validated an analytical method using desorption electrospray ionization (DESI)\u2013mass spectrometry (MS) to accurately detect, characterize, and quantify cannabinoids and also offer an easy, cost\u2010effective, and reliable technique, which can be performed in a short time for infused edibles in complex matrices such as chocolate. We evaluated a quantitative analysis of tetrahydrocannabinol (THC) in cannabis\u2010infused chocolate with thin\u2010layer chromatography (TLC)\u2013DESI\u2010MS and QuEChERS extraction method. Both techniques of TLC and QuEChERS are cost\u2010effective and can be run in short time.<\/jats:p>","DOI":"10.1002\/jms.4436","type":"journal-article","created":{"date-parts":[[2019,9,9]],"date-time":"2019-09-09T11:49:46Z","timestamp":1568029786000},"page":"834-842","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Analysis of tetrahydrocannabinol derivative from cannabis\u2010infused chocolate by QuEChERS\u2010thin layer chromatography\u2010desorption electrospray ionization mass spectrometry"],"prefix":"10.1002","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8465-7576","authenticated-orcid":false,"given":"Maryam","family":"Yousefi\u2010Taemeh","sequence":"first","affiliation":[{"name":"Centre for Research in Mass Spectrometry, Department of Chemistry York University  Toronto ON M3J 1P3 Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5804-1302","authenticated-orcid":false,"given":"Demian R.","family":"Ifa","sequence":"additional","affiliation":[{"name":"Centre for Research in Mass Spectrometry, Department of Chemistry York University  Toronto ON M3J 1P3 Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,11,8]]},"reference":[{"key":"e_1_2_7_2_1","article-title":"Tasty THC: promises and challenges of cannabis edibles","author":"Barrus D G","year":"2016","journal-title":"Methods Report (RTI Press, Publication No. OP\u20100035\u20101611)"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/1556-4029.13341"},{"key":"e_1_2_7_4_1","unstructured":"Government of Canada Department of justice www.justice.gc.ca\/eng\/cj-jp\/cannabis\/ (accessed October 31 2018)."},{"key":"e_1_2_7_5_1","unstructured":"WangX MackowskyD SearfossJ TelepchakMJ.Determination of cannabinoid content and pesticide residues in cannabis edibles and beverages LCGC.2016. Available atwww.chromatographyonline.com\/determination-cannabinoid-content-and-pesticide-residues-cannabis-edibles-and-beverages(accessed May 8 2019)."},{"key":"e_1_2_7_6_1","unstructured":"KowalskiJ DahlJH RigdonA CochranJ LaineD FagrasG.Evaluation of modified QuEChERS for pesticide analysis in cannabis LCGC.2017. 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