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The patients must show up in the clinic at the therapeutic window time to venipuncture sample. Dried plasma spot (DPS) sampling is an alternative way to replace conventional venipuncture sampling. The aim of this study was to develop and validate a DPS\u2010based liquid chromatography\u2013tandem mass spectrometry (LC\u2013MS\/MS) method to monitor VPA in a routine clinical laboratory setting. We compare the DPS with the wet plasma method of clinical samples by LC\u2013MS\/MS. The method was linear over the dynamic range of 10\u2013200 \u03bcg\/ml (covering entire therapeutic range) with a correlation coefficient <jats:italic>r<\/jats:italic><jats:sup>2<\/jats:sup> \u2265 0.995. Both the DPS and wet plasma methods were fully validated for the accuracy, precision, recovery, and matrix effect. The analyte stability was examined under conditions mimicking the sample storage, transport, and analysis procedures. A clinical study with epilepsy patients receiving VPA (<jats:italic>n<\/jats:italic> = 35) showed that, after correction for hematocrit (HCT), plasma concentrations can be successfully calculated from the DPS quantification results. Passing\u2013Bablok regression coefficients showed no proportional bias between estimated and measured plasma concentrations. Similar agreement was found by Bland\u2013Altman plots. The dried sample could be mailed to the clinical lab to test by regular mail service. So DPS can be used for drug monitoring with self\u2010sampling strategy at the patient's convenient time and place specially for ambulatory patients not attending a clinic.<\/jats:p>","DOI":"10.1002\/jms.4603","type":"journal-article","created":{"date-parts":[[2020,6,25]],"date-time":"2020-06-25T10:10:50Z","timestamp":1593079850000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Therapeutic drug monitoring of valproic acid using a dried plasma spot sampling device"],"prefix":"10.1002","volume":"56","author":[{"given":"Yanyan","family":"Li","sequence":"first","affiliation":[{"name":"Department of Clinical Laboratory The First Hospital of Jilin University  Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Breast Disease The Second Hospital of Jilin University  Changchun 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