{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T03:15:23Z","timestamp":1768706123715,"version":"3.49.0"},"reference-count":30,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2020,11,9]],"date-time":"2020-11-09T00:00:00Z","timestamp":1604880000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Mass Spectrom"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Guanxinning injection (GXNI) is widely used in the treatments of cerebral thrombosis, cerebral hemorrhage, sequela, coronary disease, stenocardia, arrhythmia, and so on. For the herbal injections, more components should be characterized and quantified as much as possible to guarantee the drug safety. However, large numbers of the chemical constituents in the GXNI still remain unknown. In this study, ultrahigh performance liquid chromatography\u2010Q Exactive hybrid quadrupole\u2010orbitrap high\u2010resolution accurate mass spectrometry (UHPLC\u2010Q Orbitrap HRMS), in combination of nuclear magnetic resonance (NMR), was used to identify the components in GXNI, which led to the identification of 194 compounds. With the aid of solvent partition, more phthalides, diterpenoid quinines, and salvianolic acids were tentatively identified, and minor compounds with the other structural types were also detected. The structural diversity of phthalides and diterpenoid quinones were revealed by the structural network, and six phthalides and 13 diterpenoid quinones were further detected in GXNI with the help of the characteristic fragmentation pattern and structural network. In addition, NMR also revealed the presence of a series of primary metabolites in the GXNI, which could be used as a complimentary approach for the rapid identification of the chemical components in the traditional Chinese medicines (TCM). However, the unknown NMR signals of GXNI needed to be further identified to guarantee the drug safety.<\/jats:p>","DOI":"10.1002\/jms.4662","type":"journal-article","created":{"date-parts":[[2022,5,10]],"date-time":"2022-05-10T05:06:00Z","timestamp":1652159160000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Characterization of chemical components in the Guanxinning injection by liquid chromatography\u2013mass spectrometry"],"prefix":"10.1002","volume":"55","author":[{"given":"Rongrong","family":"Li","sequence":"first","affiliation":[{"name":"Modern Research Center for Traditional Chinese Medicine Shanxi University  Taiyuan 030006 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yifan","family":"Cui","sequence":"additional","affiliation":[{"name":"Modern Research Center for Traditional Chinese Medicine Shanxi University  Taiyuan 030006 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaofen","family":"Zheng","sequence":"additional","affiliation":[{"name":"Yabao Pharmaceutical Group Ltd.  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