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Most MALDI ion sources operate in vacuum, which leads to the vaporization of volatile metabolites during analysis. In addition, tissue samples are often dried during sample preparation, leading to the loss of volatile metabolites even for other MSI techniques. On\u2010tissue chemical derivatization can dramatically reduce the volatility of analytes. Herein, a derivatization method is proposed utilizing N,N,N\u2010trimethyl\u20102\u2010(piperazin\u20101\u2010yl)ethan\u20101\u2010aminium iodide to chemically modify short\u2010chain fatty acids in chicken cecum, ileum, and jejunum tissue sections before sample preparation for MSI visualization.<\/jats:p>","DOI":"10.1002\/jms.4918","type":"journal-article","created":{"date-parts":[[2023,4,3]],"date-time":"2023-04-03T00:50:36Z","timestamp":1680483036000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["On\u2010tissue chemical derivatization of volatile metabolites for matrix\u2010assisted laser desorption\/ionization mass spectrometry imaging"],"prefix":"10.1002","volume":"58","author":[{"given":"Trevor T.","family":"Forsman","sequence":"first","affiliation":[{"name":"Department of Chemistry Iowa State University  Ames Iowa 50011 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew 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