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As a result, it is critical to develop an efficient and accurate method for classifying and identifying the chemical composition of LJH. In this study, ultra\u2010performance liquid chromatography\u2010quadrupole electrostatic field\u2010orbital trap high resolution mass spectrometry (UPLC\u2010Q\u2010Orbitrap\u2010MS) was successfully established, along with two data post\u2010processing techniques, characteristic fragmentations (CFs) and neutral losses (NLs), to quickly classify and identify the chemical constituents in LJH. As a result, 44 constituents of LJH were identified, including four alkaloids, 20 flavonoids, two phenylpropanoids, 17 organic acids, and one amino acid. The method in this paper enables classification and identification of chemical compositions rapidly, providing a scientific foundation for further research on the effective and toxic substances of LJH.<\/jats:p>","DOI":"10.1002\/jms.4978","type":"journal-article","created":{"date-parts":[[2023,11,10]],"date-time":"2023-11-10T02:45:15Z","timestamp":1699584315000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Rapid classification and identification of chemical constituents in <scp><i>Leonurus japonicus<\/i><\/scp> Houtt based on UPLC\u2010Q\u2010Orbitrap\u2010MS combined with data post\u2010processing techniques"],"prefix":"10.1002","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-7584-9439","authenticated-orcid":false,"given":"Yajie","family":"Dou","sequence":"first","affiliation":[{"name":"School of Chinese Materia Medica Tianjin University of Traditional Chinese Medicine  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lexin","family":"Shu","sequence":"additional","affiliation":[{"name":"School of Chinese Materia Medica Tianjin University of Traditional Chinese Medicine  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuchen","family":"Jia","sequence":"additional","affiliation":[{"name":"School of Chinese Materia Medica Tianjin University of Traditional Chinese Medicine  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4760-101X","authenticated-orcid":false,"given":"Yaqi","family":"Yao","sequence":"additional","affiliation":[{"name":"School of Chinese Materia Medica Tianjin University of Traditional Chinese Medicine  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyue","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Chinese Materia Medica Tianjin University of Traditional Chinese Medicine  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanyan","family":"Xu","sequence":"additional","affiliation":[{"name":"School of Chinese Materia Medica Tianjin University of Traditional Chinese Medicine  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0455-0969","authenticated-orcid":false,"given":"Yubo","family":"Li","sequence":"additional","affiliation":[{"name":"School of Chinese Materia Medica Tianjin University of Traditional Chinese Medicine  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,11,9]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.compbiolchem.2020.107384"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2013.12.052"},{"issue":"24","key":"e_1_2_8_4_1","first-page":"4856","article-title":"Regulatory effect of leonurus extracts on hyperuricemia in rats","volume":"39","author":"Yan M","year":"2014","journal-title":"Chin J Chin Mater Med"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2018.05.002"},{"key":"e_1_2_8_6_1","unstructured":"SunXQ.Research on nephrotoxicity of total alkaloids ofLeonuri Herbaand its mechanism. 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