{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T17:31:28Z","timestamp":1767375088659,"version":"build-2065373602"},"reference-count":42,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,5,10]],"date-time":"2024-05-10T00:00:00Z","timestamp":1715299200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2019YFC1710800"],"award-info":[{"award-number":["2019YFC1710800"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Mass Spectrom"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Bupleuri Radix is an important medicinal plant, which has been used in China and other Asian countries for thousands of years. Cultivated <jats:italic>Bupleurum chinense<\/jats:italic> DC. (<jats:italic>B. chinense<\/jats:italic>) is the main commodity of Bupleuri Radix. The benefits of intercropping with various crops for <jats:italic>B. chinense<\/jats:italic> have been recognized; however, the influence of intercropping on the chemical composition of <jats:italic>B. chinense<\/jats:italic> is still unclear yet. In this study, intercropping with sorghum and maize exhibited little effect on the root length, root diameter, and single root mass of <jats:italic>B. chinense<\/jats:italic>. Only the intercropping with sorghum increased the root length of <jats:italic>B. chinense<\/jats:italic> slightly compared to the monocropping. In addition, 200 compounds were identified by UHPLC\u2010Q\u2010TOF\u2010MS, and metabolomic combined with the Venn diagram and heatmap analysis showed apparent separation between the intercropped and monocropped <jats:italic>B. chinense<\/jats:italic> samples. Intercropping with sorghum and maize could both increase the saikosaponins, fatty acyls, and organic acids in <jats:italic>B. chinense<\/jats:italic> while decreasing the phospholipids. The influence of intercropping on the saikosaponin biosynthesis was probably related with the light intensity and hormone levels in <jats:italic>B. chinense<\/jats:italic>. Moreover, we found intercropping increased the anti\u2010inflammatory activity of <jats:italic>B. chinense<\/jats:italic>. This study provides a scientific reference for the beneficial effect of intercropping mode of <jats:italic>B. chinense<\/jats:italic>.<\/jats:p>","DOI":"10.1002\/jms.5035","type":"journal-article","created":{"date-parts":[[2024,5,10]],"date-time":"2024-05-10T05:19:01Z","timestamp":1715318341000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Intercropping with maize and sorghum\u2010induced saikosaponin accumulation in <i>Bupleurum chinense<\/i> DC. by liquid chromatography\u2010mass spectrometry\u2010based metabolomics"],"prefix":"10.1002","volume":"59","author":[{"given":"Rui","family":"Zhang","sequence":"first","affiliation":[{"name":"Modern Research Center for Traditional Chinese Medicine Shanxi University  Taiyuan China"},{"name":"Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education Shanxi University  Taiyuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiangchuan","family":"Li","sequence":"additional","affiliation":[{"name":"Shanxi Institute of Medicine and Life Sciences  Taiyuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jixu","family":"Qu","sequence":"additional","affiliation":[{"name":"Shanxi Institute of Medicine and Life Sciences  Taiyuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Doudou","family":"Zhang","sequence":"additional","affiliation":[{"name":"Shanxi Institute of Medicine and Life Sciences  Taiyuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linxu","family":"Cao","sequence":"additional","affiliation":[{"name":"Modern Research Center for Traditional Chinese Medicine Shanxi University  Taiyuan China"},{"name":"Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education Shanxi University  Taiyuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuemei","family":"Qin","sequence":"additional","affiliation":[{"name":"Modern Research Center for Traditional Chinese Medicine Shanxi University  Taiyuan China"},{"name":"Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education Shanxi University  Taiyuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0655-6942","authenticated-orcid":false,"given":"Zhenyu","family":"Li","sequence":"additional","affiliation":[{"name":"Modern Research Center for Traditional Chinese Medicine Shanxi University  Taiyuan China"},{"name":"Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education Shanxi University  Taiyuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,5,10]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/13880209.2016.1262433"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytochem.2020.112434"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1248\/yakushi.125.815"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2019.03.242"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2020.110679"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1875\u20105364(19)30073\u20101"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fsi.2019.07.080"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2010.05.019"},{"key":"e_1_2_10_10_1","first-page":"1097","article-title":"Antidepressant effect of total saponins of radix bupleuri and the underlying mechanism on a mouse model of depression","volume":"34","author":"Feng HC","year":"2020","journal-title":"J. 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