{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T09:13:43Z","timestamp":1775726023332,"version":"3.50.1"},"reference-count":37,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,4,3]],"date-time":"2025-04-03T00:00:00Z","timestamp":1743638400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,4,3]],"date-time":"2025-04-03T00:00:00Z","timestamp":1743638400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Mass Spectrom"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    In this study, the components of\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Moringa oleifera<\/jats:italic>\n                    <\/jats:styled-content>\n                    (Lam) seed were extracted using an ultrasonic\u2010assisted extraction technique with 70% methanol solution as the solvent. The antioxidant properties of the extract were evaluated through its scavenging abilities against DPPH\n                    <jats:sup>.<\/jats:sup>\n                    and ABTS. The antiproliferative effects of this extract on breast cancer MDA\u2010MB\u2010231, colon cancer SW480, leukemia HL\u201060, liver cancer SMMC\u20107721, and lung cancer A549 were assessed using the MTS assay. The distribution of MA, D\u2010trehalose, and rbGlu in the heart, kidney, liver, and spleen of mice in various intervals was visually investigated using MALDI\u2010IMS. In particular, the metabolic pathways of rbGlu were further elucidated. The result shows that rbGlu is metabolized to rbot\u2010Glu in mice within 1\u2009h. This approach further substantiates the use of MALDI\u2010MSI technique in\u00a0situ for studying the pharmacological mechanisms of bioactive component in natural products.\n                  <\/jats:p>","DOI":"10.1002\/jms.5125","type":"journal-article","created":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T23:54:58Z","timestamp":1743810898000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Determination of the Metabolic Mechanism of the Principal Components From\n                    <scp>\n                      <i>Moringa oleifera<\/i>\n                    <\/scp>\n                    (Lam) Seed by MALDI\u2010IMS"],"prefix":"10.1002","volume":"60","author":[{"given":"Tao","family":"Wang","sequence":"first","affiliation":[{"name":"Yunnan Key Laboratory of Modern Separation Analysis and Substance Transformation, College of Chemistry and Chemical Engineering Yunnan Normal University  Kunming China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinglin","family":"Wang","sequence":"additional","affiliation":[{"name":"Yunnan Key Laboratory of Modern Separation Analysis and Substance Transformation, College of Chemistry and Chemical Engineering Yunnan Normal University  Kunming China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saifei","family":"Yang","sequence":"additional","affiliation":[{"name":"Yunnan Key Laboratory of Modern Separation Analysis and Substance Transformation, College of Chemistry and Chemical Engineering Yunnan Normal University  Kunming China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinchao","family":"Wei","sequence":"additional","affiliation":[{"name":"Institute of Chemistry Chinese Academy of Sciences  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanyuan","family":"Sun","sequence":"additional","affiliation":[{"name":"School of Chemistry and Chemical Engineering Yangzhou University  Yangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2763-7787","authenticated-orcid":false,"given":"Rui","family":"Chen","sequence":"additional","affiliation":[{"name":"Yunnan Key Laboratory of Modern Separation Analysis and Substance Transformation, College of Chemistry and Chemical Engineering Yunnan Normal University  Kunming China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,4,3]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-8741(99)00106-3"},{"key":"e_1_2_9_3_1","first-page":"182","article-title":"Hepatoprotective, Antihyperlipidemic, and Anti\u2010Inflammatory Activity of Moringa oleifera in Diabetic Induced Damage in Male Wistar Rats","volume":"9","author":"Omodanisi E. 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