{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T19:35:06Z","timestamp":1790451306886,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,4,26]],"date-time":"2025-04-26T00:00:00Z","timestamp":1745625600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,4,26]],"date-time":"2025-04-26T00:00:00Z","timestamp":1745625600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81903765"],"award-info":[{"award-number":["81903765"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Mass Spectrom"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Danzhi Jiangtang capsule (DJC) is a traditional Chinese medicine prescription that has been clinically used to treat Type 2 diabetes mellitus and its complications. However, research on the chemical compounds present in DJC remains limited. In this study, an analytical strategy based on ultra\u2010performance liquid chromatography quadrupole time\u2010of\u2010flight mass spectrometry (UPLC\u2010Q\u2010TOF\/MS) was developed for the rapid and systematic characterization of chemical compounds in DJC. Firstly, a DJC self\u2010built database was established, and UPLC\u2010Q\u2010TOF\/MS was applied for comprehensive profiling of DJC's chemical compounds. Then,\n                    <jats:italic>R<\/jats:italic>\n                    language combined with MZmine was used for data preprocessing to construct the ion information list and extract effective data. Finally, the compounds were identified by multiple data processing techniques (multiple\u2010point screening mass defect filtering [MDF], extracted ion chromatogram [EIC], neutral loss filter [NLF], diagnostic fragment ion filtering [DFIF], and direct identification method [including retention time, fragment behavior and reference substances]). Eventually, 137 compounds were characterized from DJC, including 19 monoterpenoids, 26 triterpenoids, 8 flavonoids, 12 iridoids, 7 phenylethanoid glycosides, 8 acetophenones, 23 organic acids, 2 violet ketones, 13 cyclic peptides, 8 alkaloids, 2 fatty acids, and 9 other compounds. Among these, 16 compounds were verified using reference substances. The study indicated that the analytical strategy established in this study effectively supports the in\u2010depth study of DJC's chemical constituents and provides essential data for subsequent in\u00a0vivo studies.\n                  <\/jats:p>","DOI":"10.1002\/jms.5140","type":"journal-article","created":{"date-parts":[[2025,4,26]],"date-time":"2025-04-26T05:46:34Z","timestamp":1745646394000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Rapid Identification of Chemical Compounds in Danzhi Jiangtang Capsule Using Ultra\u2010Performance Liquid Chromatography Quadrupole Time\u2010of\u2010Flight Mass Spectrometry Combined With Multiple Data Processing Techniques"],"prefix":"10.1002","volume":"60","author":[{"given":"Xiaojie","family":"Fu","sequence":"first","affiliation":[{"name":"Key Laboratory of Xin'an Medicine, Ministry of Education Anhui University of Chinese Medicine  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junting","family":"Zhou","sequence":"additional","affiliation":[{"name":"Key Laboratory of Xin'an Medicine, Ministry of Education Anhui University of Chinese Medicine  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jindong","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Endocrinology The First Affiliated Hospital of Anhui University of Chinese Medicine  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-0429-4504","authenticated-orcid":false,"given":"Rui","family":"Yang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Xin'an Medicine, Ministry of Education Anhui University of Chinese Medicine  Hefei 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Education Anhui University of Chinese Medicine  Hefei China"},{"name":"Anhui Province key Laboratory of Chinese Medicinal Formula  Hefei China"},{"name":"Department of Nutrition and Food Science University of Maryland  College Park Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,26]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsps.2020.04.009"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.5582\/bst.2018.01255"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/5356825"},{"key":"e_1_2_9_5_1","first-page":"312","article-title":"Danzhi Jiangtang Capsule Reduces Renal Injury in Rats With Diabetes Induced by High Fat Diet and Streptozotocin Downregulating Toll\u2010Like Receptor 4\u2010Nuclear Factor\u2010\u03baB Pathway and Apoptosis","volume":"43","author":"Xie J.","year":"2023","journal-title":"Journal of Traditional Chinese 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