{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T00:28:04Z","timestamp":1760660884217,"version":"build-2065373602"},"reference-count":72,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T00:00:00Z","timestamp":1754956800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Mass Spectrom"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Few studies on Xiaoliu Powder (XLP) have been reported; it is necessary to clarify the material basis of XLP to lay a foundation for further clarifying its mechanism of action and supporting rational drug use. This study aims to comprehensively analyze the chemical constituents of XLP by GC\u2013MS and UPLC\u2010Q\u2010Exactive Orbitrap MS, with the aim of identifying its volatile and nonvolatile components and providing insights into its pharmacological properties. Volatile components were extracted and analyzed by GC\u2013MS, and 37 compounds were detected, accounting for 72.58% of the total peak area. Aldehydes were found to be the predominant group, followed by alkenes, esters, and phenolic compounds. Nonvolatile components were identified through UPLC\u2010Q\u2010Exactive Orbitrap MS, leading to the detection of 126 compounds, including triterpenoids, flavonoids, phenylpropanoids, organic acids, and other classes of compounds. A total of 13 compounds were accurately identified by comparison with reference standards. The findings suggest that XLP contains a diverse range of bioactive compounds, which may contribute to its therapeutic effects. A comprehensive chemical profile of XLP has been established, providing a solid foundation for further research on its pharmacological mechanisms and clinical applications.<\/jats:p>","DOI":"10.1002\/jms.5160","type":"journal-article","created":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T18:18:28Z","timestamp":1755022708000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comprehensive Strategy Analysis of Chemical Constituents of Xiaoliu Powder Based on GC\u2013MS and UPLC\u2010Q\u2010Exactive Orbitrap MS"],"prefix":"10.1002","volume":"60","author":[{"given":"Jinyuan","family":"Bai","sequence":"first","affiliation":[{"name":"School of Pharmacy Shenyang Pharmaceutical University  Shenyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yatong","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Pharmacy Shenyang Pharmaceutical University  Shenyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Na","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Pharmacy Shenyang Pharmaceutical University  Shenyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianhai","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Pharmacy Shenyang Pharmaceutical University  Shenyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boyang","family":"Shang","sequence":"additional","affiliation":[{"name":"School of Pharmacy Shenyang Pharmaceutical University  Shenyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guodong","family":"Qin","sequence":"additional","affiliation":[{"name":"Guangdong Justice Police Vocational College  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8312-0678","authenticated-orcid":false,"given":"Min","family":"Zhao","sequence":"additional","affiliation":[{"name":"School of Pharmacy Shenyang Pharmaceutical University  Shenyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,8,12]]},"reference":[{"issue":"02","key":"e_1_2_9_2_1","first-page":"190","article-title":"Progress of Pharmacological Studies on Guizhi Fuling Pills","volume":"27","author":"Zhang T.","year":"2025","journal-title":"Journal of Liaoning University of Traditional Chinese Medicine"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-020-02900-z"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3892\/or.2020.7891"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2020.110031"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines7030060"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijms.55789"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.113401"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2020.112765"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21020423"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytol.2024.05.008"},{"key":"e_1_2_9_9_3","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.7841"},{"key":"e_1_2_9_9_4","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2023.154810"},{"issue":"9","key":"e_1_2_9_10_1","first-page":"1080","article-title":"Fingerprint and Content Determination of Xiaoliu Powder","volume":"39","author":"Liu X.","year":"2022","journal-title":"Journal of Shenyang Pharmaceutical University"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2021.114942"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2020.113234"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2019.05.049"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2018.12.026"},{"issue":"05","key":"e_1_2_9_14_1","first-page":"579","article-title":"Rapid Identification of Phthalides and Organic Acids in Angelica sinensis Based on UPLC\u2010Q\u2010TOF\/MS","volume":"33","author":"Zhang Q.","year":"2022","journal-title":"China Pharmacy"},{"issue":"06","key":"e_1_2_9_15_1","first-page":"940","article-title":"Study on Chemical Constituents Differences Between Armeniacae Amarum Semen and Persicae Semen Based on High\u2010Performance Liquid Chromatography\u2010Quadrupole Time\u2010of\u2010Flight Mass Spectrometry","volume":"40","author":"Zhou X.","year":"2021","journal-title":"Journal of Instrumental Analysis"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/1758-2946-6-13"},{"issue":"08","key":"e_1_2_9_17_1","first-page":"910","article-title":"Analysis on Ingredients of Sparganii Rhizoma Absorbed Into Plasma Based on UPLC\u2010QE\u2010Orbitrap\u2010MS","volume":"43","author":"Shi H.","year":"2023","journal-title":"Chinese Journal of Hospital Pharmacy"},{"issue":"04","key":"e_1_2_9_18_1","first-page":"861","article-title":"Identification of Chemical Constituents in Guizhi Fuling Capsules by UPLC\u2010Q\u2010TOF\u2010MS\/MS","volume":"45","author":"Yang H.","year":"2020","journal-title":"China Journal of Chinese Materia Medica"},{"issue":"18","key":"e_1_2_9_19_1","first-page":"3371","article-title":"Analysis of Chemical Constituents From Citrus aurantium by UHPLC\u2010LTQ\u2010Orbitrap\u2010MS\/MS","volume":"41","author":"Yu G.","year":"2016","journal-title":"China Journal of Chinese Materia Medica"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00217-018-3116-2"},{"issue":"02","key":"e_1_2_9_21_1","first-page":"198","article-title":"Analysis of Chemical Components and Components Migrating to Blood of Guizhi Gancao Decoction by UHPLC\u2010Q\u2010Exactive Orbitrap MS","volume":"43","author":"Yin R.","year":"2025","journal-title":"Chinese Archives of Traditional Chinese Medicine"},{"issue":"09","key":"e_1_2_9_22_1","first-page":"1762","article-title":"Qualitative and Quantitative Analysis of Major Constituents of Paeoniae Radix Alba and Paeoniae Radix Rubra by HPLC\u2010DAD\u2010Q\u2010TOF\u2010MS\/MS","volume":"40","author":"Liu J.","year":"2015","journal-title":"China Journal of Chinese Materia Medica"},{"issue":"21","key":"e_1_2_9_23_1","first-page":"6473","article-title":"Rapid Identification of Chemical Components in Liuwei Dihuang Gantang Tablets by UPLC\u2010Q\u2010TOF\u2010MS\/MS","volume":"52","author":"Fan X.","year":"2021","journal-title":"Chinese Traditional and Herbal Drugs"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X16500130"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkaa1063"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.3724\/zdxbyxb-2022-0347"},{"issue":"23","key":"e_1_2_9_27_1","first-page":"7117","article-title":"Rapid Identification of Chemical Material Basis of Xiao'er Xiaoji Zhike Oral Liquid Based on UPLC\u2010Q\/TOF\u2010MS","volume":"52","author":"Wu M.","year":"2021","journal-title":"Chinese Traditional and Herbal Drugs"},{"issue":"09","key":"e_1_2_9_28_1","first-page":"2612","article-title":"Rapid Establishment of a Database of Potential Quality Markers(Q\u2010Marker) of Traditional Chinese Medicine in Curcuma Radix Based on UPLC\u2010Triple\u2010TOF\u2010MS and Network Pharmacology","volume":"53","author":"Zhang K.","year":"2022","journal-title":"Chinese Traditional and Herbal Drugs"},{"issue":"13","key":"e_1_2_9_29_1","first-page":"157","article-title":"Qualitative Analysis of Multiple Cumarins in Angelicae Sinensis Radix Based on HPLC\u2010Q\u2010TOF\u2010MS\/MS","volume":"25","author":"Jiang H.","year":"2019","journal-title":"Chinese Journal of Experimental Traditional Medical Formulae"},{"issue":"17","key":"e_1_2_9_30_1","first-page":"1605","article-title":"Chemical Constituents of Myrrh and Its Processed Product Based on UPLC\u2010Q\/TOF\u2010MS Technology and Establishment of HPLC Method for Determination of Four Components","volume":"58","author":"Yan G.","year":"2023","journal-title":"Chinese Pharmaceutical Journal"},{"issue":"12","key":"e_1_2_9_31_1","first-page":"2980","article-title":"Analysis of the Chemical Constituents of Olibanum Before and After Processing With Vinegar Based on UPLC\u2010Q\/TOF\u2010MS Combined With Multivariate Statistical Methods","volume":"46","author":"Zhu X.","year":"2023","journal-title":"Journal of Chinese Medicinal Materials"},{"issue":"18","key":"e_1_2_9_32_1","first-page":"5496","article-title":"Indentification of Chemical Components and Blood Components of Biqi Capsules by UPLC\u2010Q\/TOF\u2010MS","volume":"52","author":"Liu J.","year":"2021","journal-title":"Chinese Traditional and Herbal Drugs"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2017.11.066"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2019.01.046"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.b18-00730"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2022.11484"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1093\/jpp\/rgab129"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.115317"},{"key":"e_1_2_9_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e24461"},{"issue":"4","key":"e_1_2_9_38_3","first-page":"3165","article-title":"Paeoniflorin Inhibits Cell Viability and Invasion of Liver Cancer Cells via Inhibition of Skp2","volume":"19","author":"Liu H.","year":"2020","journal-title":"Oncology Letters"},{"issue":"6","key":"e_1_2_9_39_1","first-page":"5445","article-title":"Paeoniflorin Inhibits Proliferation of Endometrial Cancer Cells via Activating MAPK and NF\u2010\u03baB Signaling Pathways","volume":"14","author":"Zhang J.","year":"2017","journal-title":"Experimental and Therapeutic Medicine"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psj.2024.104683"},{"issue":"6","key":"e_1_2_9_41_1","first-page":"413","article-title":"Germacrone Protects Renal Tubular Cells Against Ferroptotic Death and ROS Release by Re\u2010Activating Mitophagy in Diabetic Nephropathy","volume":"57","author":"Wang Y.","year":"2023","journal-title":"Free Radical Research"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2023.110876"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2024.117136"},{"key":"e_1_2_9_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2025.114549"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.7686"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.4c07915"},{"issue":"03","key":"e_1_2_9_46_1","first-page":"472","article-title":"Rapid Identification of Components in Houyanqing Oral Liquid by UHPLC Q\u2010Exactive Orbitrap MSn and Molecular Networking","volume":"27","author":"Quan J.","year":"2025","journal-title":"Modern Chinese Medicine"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.6647"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.6977"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12010-024-05003-4"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2024.1365949"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12071959"},{"issue":"4","key":"e_1_2_9_52_1","first-page":"56","article-title":"Analysis of the Chemical Constituents of Chuanhu Qutong Granules Based on UPLC\u2010Q\u2010Exactive Orbitrap\u2010MS","volume":"38","author":"Cai W.","year":"2024","journal-title":"Research and Practice on Chinese Medicines"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.3c08886"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.3390\/cimb46070405"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1093\/jpp\/rgab020"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1002\/fsn3.3615"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2023.1194861"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2022.1060783"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2021.119921"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1FO02120F"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms242417537"},{"key":"e_1_2_9_61_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.8b04020"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1177\/1934578X20903555"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sajb.2020.03.023"},{"key":"e_1_2_9_63_2","doi-asserted-by":"publisher","DOI":"10.1080\/13102818.2019.1673209"}],"container-title":["Journal of Mass Spectrometry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jms.5160","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T16:03:58Z","timestamp":1760630638000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/jms.5160"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,12]]},"references-count":72,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["10.1002\/jms.5160"],"URL":"https:\/\/doi.org\/10.1002\/jms.5160","archive":["Portico"],"relation":{},"ISSN":["1076-5174","1096-9888"],"issn-type":[{"type":"print","value":"1076-5174"},{"type":"electronic","value":"1096-9888"}],"subject":[],"published":{"date-parts":[[2025,8,12]]},"assertion":[{"value":"2025-03-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e5160"}}