{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T03:05:22Z","timestamp":1773198322385,"version":"3.50.1"},"reference-count":15,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T00:00:00Z","timestamp":1768780800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T00:00:00Z","timestamp":1768780800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Mass Spectrom"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>The misuse of beta\u2010agonist drugs as growth promoters in livestock production, highlighted by the cases of intoxication in Europe in the 1990s, has resulted in strict regulations in the European Union. These restrictions have required the development of increasingly sensitive analytical methods. In June 2022, the European Union Reference Laboratory (EURL BVL Berlin) released the Guidance Document on Minimum Method Performance Requirements (MMPRs), a technical guidance for analytical methods in residue control. The MMPRs represent the minimum concentrations that official laboratories should be able to reliably identify to analyze prohibited substances in different animal matrices. In this work, a qualitative screening method for 21 beta\u2010agonists at half of MMPRs was developed and validated in animal lung and liver by UPLC\u2013MS\/MS technique according to Commission Implementing Regulation (EU) 2021\/808 requirements. With regard to detection capability CC\u03b2, the results obtained permitted the qualitative determination of 11 clenbuterol\u2010like beta\u2010agonists (Clenbuterol, Bromchlorbuterol, Brombuterol, Cimaterol, Cimbuterol, Clenpenterol, Clenproperol, Hydroxymethylclenbuterol, Mabuterol, Mapenterol, Tulobuterol) at 0.05\u2009\u03bcg\/kg and for 10 salbutamol\u2010like beta\u2010agonists (Carbuterol, Isoxsuprine, Clencyclohexerol, Ractopamine, Ritodrine, Salbutamol, Terbutaline, Zilpaterol, Fenoterol, Salmeterol) at 0.25\u2009\u03bcg\/kg. The method was validated for lungs and livers of different animal species (cattle, chicken, sheep, and swine): following the requirements of the above\u2010mentioned Regulation. The method was found to be robust and specific.<\/jats:p>","DOI":"10.1002\/jms.70029","type":"journal-article","created":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T00:46:54Z","timestamp":1768870014000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Veterinary Drug Residues in Animal\u2010Origin Food: a UPLC\u2013MS\/MS Screening Method for the Determination of 21 Beta\u2010Agonists in Animal Lung and Liver According to Commission Implementing Regulation (EU) 2021\/808"],"prefix":"10.1002","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-6704-2528","authenticated-orcid":false,"given":"V.","family":"Pieragostini","sequence":"first","affiliation":[{"name":"Istituto Zooprofilattico Sperimentale dell'Umbria e delle Marche \u201cTogo Rosati\u201d  Perugia 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88\/299\/EEC","volume":"125","year":"1996","journal-title":"Official Journal of the European Communities"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4274(99)00270-2"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/02652030500135102"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2018.03.026"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/foods12224052"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.2527\/1998.761195x"},{"key":"e_1_2_6_11_1","first-page":"84","article-title":"Commission Implementing Regulation (EU) 2021\/808 of 22 March 2021 on the Performance of Analytical Methods for Residues of Pharmacologically Active Substances Used in Food\u2010Producing Animals and on the Interpretation of Results as Well as on the Methods to Be Used for Sampling, and Repealing Decisions 2002\/657\/EC and 98\/179\/EC","volume":"180","year":"2021","journal-title":"Official Journal of the European Union"},{"key":"e_1_2_6_12_1","first-page":"41","article-title":"Commission Regulation (EU) 2019\/1871 of 7 November 2019 on Reference Points for Action for Non\u2010Allowed Pharmacologically Active Substances Present in Food of Animal Origin and Repealing Decision 2005\/34\/EC","volume":"289","year":"2019","journal-title":"Official Journal of the European Union"},{"key":"e_1_2_6_13_1","unstructured":"EURL \u201cGuidance on Minimum Method Performance Requirements (MMPRs) For Specific Pharmacologically Active Substances in Specific Animal Matrices \u201d (2022) https:\/\/eurl\u2010residues.eu\/wp\u2010content\/uploads\/2020\/12\/EURL_MMPR_guidance\u2010paper_final.pdf."},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodcont.2022.109488"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.microc.2014.02.012"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2016.09.041"}],"container-title":["Journal 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