{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T03:05:26Z","timestamp":1773198326956,"version":"3.50.1"},"reference-count":41,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T00:00:00Z","timestamp":1769558400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T00:00:00Z","timestamp":1769558400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Mass Spectrom"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Proton\u2010transfer\u2010reaction\u2014mass spectrometry (PTR\u2010MS) provides real\u2010time analysis of volatile organic compounds (VOCs) relevant to atmospheric research, food and flavor characterization, industrial process control, and medical applications. However, PTR\u2010MS is inherently limited in its ability to resolve isomers of molecules with the same mass\u2010to\u2010charge ratio (\n                    <jats:italic>m\/z<\/jats:italic>\n                    ). To address this selectivity constraint, we coupled a time\u2010of\u2010flight (TOF) based PTR\u2010MS setup with a \u201cStructures for Lossless Ion Manipulations Ion Mobility Spectrometry\u201d (SLIM IMS) module. The integration of SLIM IMS introduces an additional separation dimension without compromising the real\u2010time capability of PTR\u2010MS.\n                  <\/jats:p>\n                  <jats:p>\n                    A custom designed SLIM device enabled efficient confinement and transmission of low mass ions (\n                    <jats:italic>m\/z<\/jats:italic>\n                    \u2009&lt;\u2009300), which are typically analyzed in PTR\u2010MS. The developed system achieved helium\u2010based ion mobility resolutions (CCS\n                    <jats:sub>He<\/jats:sub>\n                    \/\u0394CCS\n                    <jats:sub>He<\/jats:sub>\n                    ) of 190 for a path length of 9\u2009m, corresponding to nitrogen\u2010based resolutions (CCS\n                    <jats:sub>N2<\/jats:sub>\n                    \/\u0394CCS\n                    <jats:sub>N2<\/jats:sub>\n                    ) of approximately 600. On average 65% of the ions transmitted in straight\u2010through mode were still detected after accumulation and transport through the 9\u2010m serpentine IMS structure. Limits of detection were determined to be in the low parts\u2010per\u2010trillion by volume (pptv) range.\n                  <\/jats:p>\n                  <jats:p>\n                    The enhanced resolving power of the PTR\u2010SLIM\u2010TOF was demonstrated by the successful separation of the protonated isomeric system 3\u2010methyl\u20102\u2010butanone and 2\u2010pentanone (\n                    <jats:italic>m\/z<\/jats:italic>\n                    87.080) within multiple IMS laps. Furthermore, as a real\u2010life test, the headspace above freshly brewed coffee was analyzed. Separation of the isomeric flavor compounds, 2\u2010ethyl\u20103\u2010methylpyrazine, 2,3,5\u2010trimethylpyrazine, and 2\u2010ethyl\u20105(6)\u2010methylpyrazine was confirmed by introducing reference samples.\n                  <\/jats:p>\n                  <jats:p>These results demonstrate that coupling PTR\u2010TOF\u2010MS with SLIM\u2010IMS substantially enhances compound selectivity while retaining the real\u2010time and sensitivity capabilities of PTR\u2010MS. The PTR\u2010SLIM\u2010TOF platform represents a significant advancement in ion mobility assisted mass spectrometry for high\u2010throughput chemical analysis across diverse scientific and industrial applications.<\/jats:p>","DOI":"10.1002\/jms.70031","type":"journal-article","created":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T07:59:33Z","timestamp":1769673573000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Selectivity Beyond Mass: Real\u2010Time Isomer Separation Using SLIM IMS Coupled to PTR\u2010MS"],"prefix":"10.1002","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-2976-9422","authenticated-orcid":false,"given":"Jacob","family":"Jordan","sequence":"first","affiliation":[{"name":"IONICON Analytik GmbH  Innsbruck Austria"},{"name":"Institut f\u00fcr Ionenphysik und Angewandte Physik Universit\u00e4t Innsbruck  Innsbruck Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfons","family":"Jordan","sequence":"additional","affiliation":[{"name":"IONICON Analytik GmbH  Innsbruck Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Lindinger","sequence":"additional","affiliation":[{"name":"IONICON Analytik GmbH  Innsbruck Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gernot","family":"Hanel","sequence":"additional","affiliation":[{"name":"IONICON Analytik GmbH  Innsbruck Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tobias","family":"F\u00fcgenschuh","sequence":"additional","affiliation":[{"name":"IONICON Analytik GmbH  Innsbruck Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9373-9266","authenticated-orcid":false,"given":"Martin\u00a0K.","family":"Beyer","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Ionenphysik und Angewandte Physik Universit\u00e4t Innsbruck  Innsbruck Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-2475-295X","authenticated-orcid":false,"given":"Philipp","family":"Sulzer","sequence":"additional","affiliation":[{"name":"IONICON Analytik GmbH  Innsbruck Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,1,28]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0168\u20101176(95)04294\u2010U"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168\u20101176(97)00281\u20104"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijms.2009.06.00"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac300894t"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.6b05110"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.8b02641"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.3c02669"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1088\/1752\u20107163\/ab21a"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac0501240"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2018.06.056"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2013.09.072"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00216\u2010015\u20108942\u20105"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.agrformet.2015.10.016"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/jms.4258"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.egypro.2016.11.068"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac0498260"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijms.2009.07.005"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168\u20101176(97)00166\u20103"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13361\u2010019\u201002288\u20102"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/rcm.1641"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac502054p"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/mas.21902"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaerosci.2024.106353"},{"key":"e_1_2_8_25_1","unstructured":"M.KamrathandF.Lopez\u2010Hilfiker \u201cIsomer Separation With Vocus Ion Mobility Spectrometry. 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