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It is intended to support researchers from chemistry and related disciplines in developing a coherent understanding of MS principles, instrumentation, and data interpretation. The architecture of mass spectrometers is outlined, including ion generation, mass analysis, and detection, together with the fundamental processes by which analytes are converted into gas\u2010phase ions. Emphasis is placed on practical interpretation of mass spectra, including isotopic pattern analysis, molecular mass and elemental composition determination, and the evaluation of spectral peak characteristics such as resolution. The role of tandem mass spectrometry (MS\/MS) in structural elucidation, particularly in the context of ESI\u2010induced fragmentation pathways, is discussed. Terminology is aligned with IUPAC recommendations to ensure conceptual clarity. 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