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The ELVIS probe is portable, inexpensive, easy to operate and to point to a target area and exhibits no detectable carryovers. The probe can also be readily coupled to most atmospheric\u2010pressure ionization sources, as demonstrated herein for electrospray ionization (ESI). The ELVIS probe employs Venturi pumping to provide efficient and controllable aspiration of the laser\u2010generated plume. This mechanism transports analyte vapors directly to the ion source, substantially reducing signal dispersion that commonly occurs during open\u2010air sampling or when carrier gases are used. Desorption is achieved using a compact, low\u2010cost, yet highly effective 0.5 W laser pointer, enabling the sampling of a wide range of analytes from diverse matrices. Notably, the ELVIS probe is particularly advantageous for sampling target analytes deeply embedded within complex matrices, where spray\u2010based or liquid\u2010extraction ambient MS techniques often fail. For proper ionization, the probe was coupled to a commercial ESI source and successfully applied to the detection of illicit drugs, plasticizers in PVC, caffeine directly from a coffee bean, and pesticide residues on the wings of a deceased honeybee. The advantageous coupling of the ELVIS probe with Venturi\u2010assisted easy ambient sonic\u2010spray ionization is also discussed.<\/jats:p>","DOI":"10.1002\/jms.70085","type":"journal-article","created":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T09:34:17Z","timestamp":1785231257000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The ELVIS Probe: Combining Laser Pointer Desorption, Venturi\u2010Assisted Plume Transport, and Electrospray Ionization in a Simple Handheld Tool for Remote Ambient Mass Spectrometry"],"prefix":"10.1002","volume":"61","author":[{"given":"Andrea Ferreira","family":"Machado","sequence":"first","affiliation":[{"name":"PPGEMN, School of Engineering, Mackenzie Presbyterian University and MackGraphe \u2010 Mackenzie Institute for Research in Graphene and Nanotechnologies Mackenzie Presbyterian Institute  S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcos Fernando","family":"Franco","sequence":"additional","affiliation":[{"name":"Technical\u2010Scientific Police Superintendency, SPTC  S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2287-3641","authenticated-orcid":false,"given":"Jorge Jardim","family":"Zacca","sequence":"additional","affiliation":[{"name":"Brazilian Federal Police  Bras\u00edlia Distrito Federal Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deleon Nascimento","family":"Correa","sequence":"additional","affiliation":[{"name":"Technical\u2010Scientific Police Superintendency, SPTC  S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco\u2010Aur\u00e9lio","family":"De Paoli","sequence":"additional","affiliation":[{"name":"Institute of Chemistry University of Campinas  Campinas S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cl\u00e9cio Fernando","family":"Klitzke","sequence":"additional","affiliation":[{"name":"Department of Chemistry Federal University of Paran\u00e1  Curitiba Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4716-4080","authenticated-orcid":false,"given":"Marcos N.","family":"Eberlin","sequence":"additional","affiliation":[{"name":"PPGEMN, School of Engineering, Mackenzie Presbyterian University and MackGraphe \u2010 Mackenzie Institute for Research in Graphene and Nanotechnologies Mackenzie Presbyterian Institute  S\u00e3o Paulo S\u00e3o Paulo Brazil"},{"name":"Institute for Creation Research  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,28]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00216\u2010010\u20103600\u20104"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ansa.70007"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/dta.1390"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1104404"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trac.2017.02.008"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2009.11.033"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac050162j"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1039\/C0AN00365D"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.1c01937"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aan3968"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac00096a049"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac102765z"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/rcm.2250"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jasms.2006.08.007"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac0711815"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1039\/B715527F"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.4071"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jasms.2008.06.010"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/rcm.7077"},{"key":"e_1_2_9_21_1","volume-title":"Fluid Mechanics","author":"White F. 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