{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T06:21:07Z","timestamp":1787898067407,"version":"build-2784847793"},"reference-count":16,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,7,19]],"date-time":"2026-07-19T00:00:00Z","timestamp":1784419200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,19]],"date-time":"2026-07-19T00:00:00Z","timestamp":1784419200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Mass Spectrom"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>The interaction between solvent, solute and physical phenomena (e.g., photon\u2010emitting biomolecules) constitute one of the most fundamental, yet challenging, frontiers in modern biophysics and analytical chemistry. However, standard mass spectrometry instrumentation is often insufficient to yield useful data in this domain due to the solvent molecule bind alteration induced by high electric field presents in the usually employed ionization sources (e.g., Electrospray and Atmospheric Pressure Chemical Ionization). The challenge is to transport analyte ions from the condensed liquid phase into the high\u2010vacuum gas phase of the mass analyzer with minimal voltages\u2010induced loss of supramolecular structure or structural scrambling while preserving the solvent environment structure. In this work, we employed no\u2010discharge ND\u2010APCI that has been rigorously validated in regulatory environments operating in no voltage ionization conditions to investigate the interaction of Albumin and water molecule environment under the irradiation of photon emitted by means of quantum dots technology at different simultaneous wave lights (800\u2009nm, 525\u2009nm, 445\u2009nm). The obtained results, in terms of albumin\u2013solvent (water) interaction, are consistent with a protein\u2010dependent change in the proton affinity of albumin and are corroborated by complementary pH and colorimetric (Coomassie) measurements; their possible mechanistic origin is discussed.<\/jats:p>","DOI":"10.1002\/jms.70091","type":"journal-article","created":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T00:06:07Z","timestamp":1784505967000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Zero\u2010Potential No\u2010Discharge APCI Combined With pH and Colorimetric Measurements Reveals a Protein\u2010Dependent Change in Albumin Proton Affinity Under Quantum\u2010Dot Patch Exposure"],"prefix":"10.1002","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0550-3788","authenticated-orcid":false,"given":"Mauro","family":"Libertucci","sequence":"first","affiliation":[{"name":"SmiLife S.r.l.  Tivoli Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-2154-4807","authenticated-orcid":false,"given":"Dario Maximilian","family":"Spera","sequence":"additional","affiliation":[{"name":"H.I.T. S.r.l.  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1032-4431","authenticated-orcid":false,"given":"Germano","family":"Orr\u00f9","sequence":"additional","affiliation":[{"name":"Surgical Sciences departments University of Cagliari  Cagliari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,19]]},"reference":[{"key":"e_1_2_1_5_2_1","doi-asserted-by":"publisher","DOI":"10.1117\/1.JBO.25.7.071203"},{"key":"e_1_2_1_5_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/ar040026l"},{"key":"e_1_2_1_5_4_1","doi-asserted-by":"publisher","DOI":"10.15167\/2421\u20104248\/jpmh2022.63.2S3.2771"},{"key":"e_1_2_1_5_5_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1515706113"},{"key":"e_1_2_1_5_6_1","doi-asserted-by":"publisher","DOI":"10.1529\/biophysj.106.093187"},{"key":"e_1_2_1_5_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac300468a"},{"key":"e_1_2_1_5_8_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.anchem.111808.073702"},{"key":"e_1_2_1_5_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/mas.20143"},{"key":"e_1_2_1_5_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/rcm.2438"},{"key":"e_1_2_1_5_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/jaoac\/88.5.1312"},{"key":"e_1_2_1_5_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2024.1427411"},{"key":"e_1_2_1_5_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph20010391"},{"key":"e_1_2_1_5_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph19074123"},{"key":"e_1_2_1_5_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/978\u20103\u2010319\u201072041\u20108_19"},{"key":"e_1_2_1_5_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.9b06584"},{"key":"e_1_2_1_5_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.9b02443"}],"container-title":["Journal of Mass Spectrometry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jms.70091","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jms.70091","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jms.70091","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T06:03:20Z","timestamp":1787897000000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/jms.70091"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,19]]},"references-count":16,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1002\/jms.70091"],"URL":"https:\/\/doi.org\/10.1002\/jms.70091","archive":["Portico"],"relation":{},"ISSN":["1076-5174","1096-9888"],"issn-type":[{"value":"1076-5174","type":"print"},{"value":"1096-9888","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,19]]},"assertion":[{"value":"2026-03-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70091"}}