{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T05:11:57Z","timestamp":1788930717751,"version":"build-2803163510"},"reference-count":29,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T00:00:00Z","timestamp":1788566400000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Mass Spectrom"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The dried roots of\n                    <jats:italic>Stemona tuberosa<\/jats:italic>\n                    , known as \u201cBai\u2010Bu\u201d in traditional Chinese medicine, have been employed as a therapeutic agent for the treatment of pertussis and tuberculosis. The chemical composition of\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>S.\u2009tuberosa<\/jats:italic>\n                    <\/jats:styled-content>\n                    is dominated by alkaloids which have been reported to possess antifibrosis effect. Herein, ELISA kit and immunofluorescence analyses showed that the alkaloid of stemoninoamide (Stem) isolated from\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>S.\u2009tuberosa<\/jats:italic>\n                    <\/jats:styled-content>\n                    exhibited inhibitory effect on the production of \u03b1\u2010SMA and Col\u20101 of HFL1 cells stimulated by TGF\u2010\u03b21. Further lipidomic analysis based on LC\u2013MS\/MS revealed differential metabolites via multivariate statistical analysis. Pathway enrichment analyses indicated that differential metabolites were mostly implicated in S1P\/S1PR signaling pathway, which could be potentially associated with the antifibrosis mechanism of Stem.\n                  <\/jats:p>","DOI":"10.1002\/jms.70108","type":"journal-article","created":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T05:34:50Z","timestamp":1788672890000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["LC\u2013MS\/MS\u2010Based Lipidomic Profiling Reveals the Regulatory Effect of Stemoninoamide on TGF\u2010\u03b21\u2010Induced Myofibroblast Transition in HFL1 Cells"],"prefix":"10.1002","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-2763-6609","authenticated-orcid":false,"given":"Wen","family":"Kang","sequence":"first","affiliation":[{"name":"Key Laboratory of Mass Spectrometry Imaging and Metabolomics (Minzu University of China) State Ethnic Affairs Commission  Beijing 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