{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T00:48:58Z","timestamp":1791679738957,"version":"4.3.4"},"reference-count":37,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T00:00:00Z","timestamp":1788912000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T00:00:00Z","timestamp":1788912000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Mass Spectrom"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Cyclocarya paliurus<\/jats:italic>\n                    (\n                    <jats:italic>C. paliurus<\/jats:italic>\n                    ) is a novel food resource with traditional medicinal properties, including heat\u2010clearing, detumescence, and analgesia. It has exhibited significant therapeutic effects in the treatment of metabolic diseases such as hyperglycemia, hyperlipidemia, and hypertension, making it a crucial ingredient in pharmaceutical and health food formulations. However, quality control studies focusing on the multi\u2010component pharmacologically active substances in\n                    <jats:italic>C. paliurus<\/jats:italic>\n                    remain limited. Here, this study employed ultra\u2010performance liquid chromatography\u2010quadrupole\u2010Orbitrap mass spectrometry (UPLC\u2010Q\u2010Orbitrap\u2010MS), gas chromatography\u2013mass spectrometry (GC\u2013MS), and gas chromatography\u2013ion mobility spectrometry (GC\u2013IMS) technologies to profoundly characterize major pharmacologically active substances and quantitatively assess the quality of\n                    <jats:italic>C. paliurus<\/jats:italic>\n                    . A total of 88 compounds were identified from\n                    <jats:italic>C. paliurus<\/jats:italic>\n                    by UPLC\u2010Q\u2010Orbitrap MS, whereas 129 volatile constituents were detected through GC\u2013MS and GC\u2013IMS analysis. Furthermore, an adjusted parallel reaction monitoring (PRM) method was developed and validated for the quantification of eight key effective components of different types in\n                    <jats:italic>C. paliurus<\/jats:italic>\n                    , which were selected as benchmark substances for quality evaluation. In summary, this work offers a universally applicable method for identifying global metabolites and determining the multicomponent composition of complex in traditional Chinese medicine ingredients, providing a pragmatic workflow for assessing the quality and consistency.\n                  <\/jats:p>","DOI":"10.1002\/jms.70109","type":"journal-article","created":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T04:40:30Z","timestamp":1789015230000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Detailed Chemical Composition Characterization and Multicomponent Quality Control of\n                    <i>Cyclocarya paliurus<\/i>\n                    by Combining UPLC\u2010Q\u2010Orbitrap MS, GC\u2013MS, and GC\u2013IMS"],"prefix":"10.1002","volume":"61","author":[{"given":"Jun","family":"Zhu","sequence":"first","affiliation":[{"name":"Department of TCMs Pharmaceuticals, School of Traditional Chinese Pharmacy China Pharmaceutical University  Nanjing China"},{"name":"China Tobacco Jiangsu Industrial Co. 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