{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T04:40:51Z","timestamp":1792471251591,"version":"4.5.0"},"reference-count":73,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T00:00:00Z","timestamp":1792368000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T00:00:00Z","timestamp":1792368000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Mass Spectrom"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Ambient and direct\u2010analysis mass spectrometry has shifted from predominantly proof\u2010of\u2010concept rapid screening to increasingly robust analytical platforms with clearer translational potential. This focused critical review examines the following four emerging or strategically relevant platforms: dielectric\u2010barrier\u2010discharge ionization (DBDI), liquid electron ionization (LEI), paper cone spray ionization (PCSI), and sandpaper spray ionization (SPS). DBDI, PCSI, and SPS are ambient or ambient\u2010like direct\u2010sampling approaches. LEI is included as a complementary direct\u2010analysis platform because its electron\u2010ionization chemistry provides structurally informative fragmentation and can address limitations of soft\u2010ionization methods. The review emphasizes recent advances in source and substrate engineering, analytical reproducibility, quantitative readiness, portability, and application\u2010driven implementation. The review uses representative evidence from the literature to distinguish demonstrated analytical performance from broader translational potential, while recognizing that reported detection limits and precision values depend on the method, matrix, and analyte. Rather than cataloging all ambient ionization methodologies, the article critically evaluates the mechanistic strengths, limitations, maturity, and realistic implementation prospects of the four selected platforms in forensic, environmental, pharmaceutical, and field\u2010analytical contexts. Collectively, these technologies illustrate a broader maturation of direct\u2010analysis mass spectrometry, and their long\u2010term impact will increasingly depend on quantitative validation, reproducibility, workflow standardization, and integration with practical analytical needs.<\/jats:p>","DOI":"10.1002\/jms.70125","type":"journal-article","created":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T04:31:40Z","timestamp":1792470700000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["From Innovation to Translation: Emerging Direct\u2010Analysis Mass Spectrometry Platforms"],"prefix":"10.1002","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7777-4819","authenticated-orcid":false,"given":"Thais","family":"Lino","sequence":"first","affiliation":[{"name":"Mackenzie Institute for Research in Graphene and Nanotechnologies (MackGraphe), School of Engineering, Mackenzie Presbyterian University  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0329-5687","authenticated-orcid":false,"given":"Adriano Reis Jos\u00e9","family":"da Silva","sequence":"additional","affiliation":[{"name":"Mackenzie Institute for Research in Graphene and Nanotechnologies (MackGraphe), School of Engineering, Mackenzie Presbyterian University  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-7586-4485","authenticated-orcid":false,"given":"Davi Rodrigues","family":"da Silva","sequence":"additional","affiliation":[{"name":"Mackenzie Institute for Research in Graphene and Nanotechnologies (MackGraphe), School of Engineering, Mackenzie Presbyterian University  S\u00e3o Paulo Brazil"},{"name":"Scientific Police of the State of Goi\u00e1s  Goi\u00e2nia Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-2222-7861","authenticated-orcid":false,"given":"Welisson Vilarindo","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Mackenzie Institute for Research in Graphene and Nanotechnologies (MackGraphe), School of Engineering, Mackenzie Presbyterian University  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6699-2474","authenticated-orcid":false,"given":"Diego Gomes","family":"Rocha","sequence":"additional","affiliation":[{"name":"Department of Chemistry Federal University of Minas Gerais  Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9448-9518","authenticated-orcid":false,"given":"Rodinei","family":"Augusti","sequence":"additional","affiliation":[{"name":"Department of Chemistry Federal University of Minas Gerais  Belo Horizonte Brazil"},{"name":"Federal Center for Technological Education of Minas Gerais  Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,19]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/mas.20108"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac200918u"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr300309q"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cll.2025.01.004"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.greeac.2024.100140"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1104404"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac050162j"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.acr.2016.11.011"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.9b00807"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ansa.202300004"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ansa.70007"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/jasms.4c00277"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2014.237164"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac071181r"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac5016408"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.forc.2020.100294"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/jasms.2c00149"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1021\/jasms.4c00006"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1021\/jasms.3c00070"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.talo.2024.100377"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/jasms.1c00290"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/jms.5133"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.5c04847"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1039\/D5AY00193E"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tifs.2024.104480"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.9b05454"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.5c02782"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.talanta.2024.125774"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.4c00215"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1021\/jasms.5c00171"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010anchem\u2010061522\u2010040824"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.6b03091"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2017.12.005"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsmeasuresciau.4c00028"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.3390\/life16010168"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1021\/jasms.5c00111"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.1c05216"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.1c05353"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.2c04795"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.3c02616"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.3c03454"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2026.466719"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202502028"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/mas.21886"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trac.2024.117814"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/dta.3644"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1039\/C3MD00235G"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trac.2021.116420"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1872\u20102040(18)61122\u20103"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1021\/jasms.3c00087"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1039\/D4AN00901K"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.1039\/D5AN01179E"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jasms.2007.07.027"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/jms.1243"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.1021\/jasms.4c00475"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trac.2023.117420"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.1039\/D3AN02109B"},{"key":"e_1_2_12_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2019.01.034"},{"key":"e_1_2_12_60_1","doi-asserted-by":"publisher","DOI":"10.3390\/separations12050105"},{"key":"e_1_2_12_61_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.5b04759"},{"key":"e_1_2_12_62_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010023\u201033647\u20105"},{"key":"e_1_2_12_63_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010025\u201014772\u20109"},{"key":"e_1_2_12_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trac.2019.06.028"},{"key":"e_1_2_12_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijms.2021.116781"},{"key":"e_1_2_12_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lmd.2024.100010"},{"key":"e_1_2_12_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2021.129708"},{"key":"e_1_2_12_68_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.4c06062"},{"key":"e_1_2_12_69_1","doi-asserted-by":"publisher","DOI":"10.1039\/d1an00255d"},{"key":"e_1_2_12_70_1","doi-asserted-by":"publisher","DOI":"10.1021\/jasms.3c00317"},{"key":"e_1_2_12_71_1","doi-asserted-by":"publisher","DOI":"10.1021\/jasms.3c00188"},{"key":"e_1_2_12_72_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200906314"},{"key":"e_1_2_12_73_1","doi-asserted-by":"publisher","DOI":"10.1002\/jms.5000"},{"key":"e_1_2_12_74_1","doi-asserted-by":"publisher","DOI":"10.1111\/1556\u20104029.15592"}],"container-title":["Journal of Mass Spectrometry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jms.70125","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jms.70125","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jms.70125","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T04:31:53Z","timestamp":1792470713000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/jms.70125"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,19]]},"references-count":73,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2026,11]]}},"alternative-id":["10.1002\/jms.70125"],"URL":"https:\/\/doi.org\/10.1002\/jms.70125","archive":["Portico"],"relation":{},"ISSN":["1076-5174","1096-9888"],"issn-type":[{"value":"1076-5174","type":"print"},{"value":"1096-9888","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,19]]},"assertion":[{"value":"2026-06-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70125"}}