{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T06:52:56Z","timestamp":1784357576830,"version":"3.55.0"},"reference-count":9,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,11,14]],"date-time":"2005-11-14T00:00:00Z","timestamp":1131926400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Mass Spectrom."],"published-print":{"date-parts":[[2006,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A method for the determination of ethyl glucuronide (EtG) in hair samples, using liquid chromatography\/electrospray tandem mass spectrometry (LC\/ESI\u2010MS\/MS), was developed and validated. The treatment of hair samples was as follows: to 100 mg of washed (dichloromethane followed by methanol, 1 ml each) and cut (1\u20132 mm) material, 700 \u00b5l of water, 20 \u00b5l of internal standard solution (pentadeuterated EtG, D<jats:sub>5<\/jats:sub>\u2010EtG, 500 \u00b5g\/l) and 20 \u00b5l of methanol were added. Samples were incubated at 25 \u00b0C overnight and then ultrasonicated for 2 h. Finally, 8 \u00b5l of the centrifuged solution (13 000 rpm) were analyzed by LC\/ESI\u2010MS\/MS in negative ion mode. The surviving ions of EtG and D<jats:sub>5<\/jats:sub>\u2010EtG were monitored together with the following MRM transitions: <jats:italic>m<\/jats:italic>\/<jats:italic>z<\/jats:italic> 221 \u2192 75, <jats:italic>m<\/jats:italic>\/<jats:italic>z<\/jats:italic> 221 \u2192 85 (EtG) and <jats:italic>m<\/jats:italic>\/<jats:italic>z<\/jats:italic> 226 \u2192 75, <jats:italic>m<\/jats:italic>\/<jats:italic>z<\/jats:italic> 226 \u2192 85 (D<jats:sub>5<\/jats:sub>\u2010EtG). The method exhibited a mean correlation coefficient better than 0.9998 over the dynamic range (3\u20132000 pg\/mg). The lower limit of quantification (LLOQ) and the limit of detection (LOD) were 3 and 2 pg\/mg respectively. The intra\u2010 and interday precision and accuracy were studied at four different concentration levels (3, 5, 56 and 160 pg\/mg) and were always better than 7% (<jats:italic>n<\/jats:italic> = 5). Matrix effects did not exceed 20%. The method was applied to several hair samples taken from autopsies of known alcoholics, from patients in withdrawal treatment, from social drinkers, from adult teetotalers and from children not exposed to ethanol, with EtG concentrations globally ranging from \u22642 to 4180 pg\/mg. Copyright \u00a9 2005 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/jms.943","type":"journal-article","created":{"date-parts":[[2005,11,16]],"date-time":"2005-11-16T18:27:07Z","timestamp":1132165627000},"page":"34-42","source":"Crossref","is-referenced-by-count":97,"title":["Determination of ethyl glucuronide in hair samples by liquid chromatography\/electrospray tandem mass spectrometry"],"prefix":"10.1002","volume":"41","author":[{"given":"Luca","family":"Morini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"Politi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelo","family":"Groppi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristiana","family":"Stramesi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aldo","family":"Polettini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,11,14]]},"reference":[{"key":"e_1_2_7_2_2","first-page":"119","volume-title":"Proceedings of Symposium \u201cDas Haar als Spur. Spur der Haare\u201d, November 24, 1993","author":"Sachs H","year":"1997"},{"key":"e_1_2_7_3_2","first-page":"39","volume-title":"Proceedings of the 1994 Joint TIAFT\/SOFT International Meeting, October 31 to November 4, 1994","author":"Aderjan RE","year":"1995"},{"key":"e_1_2_7_4_2","first-page":"175","volume-title":"Proceedings of the 1995 GTFCh Symposium, April 20\u201322, 1995","author":"Skopp G","year":"1995"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/rcm.1932"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.forsciint.2004.04.031"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/alcalc\/35.3.283"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.forsciint.2004.04.032"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0379-0738(02)00163-9"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0379-0738(96)02070-1"}],"container-title":["Journal of Mass Spectrometry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjms.943","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jms.943","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T17:16:57Z","timestamp":1760635017000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/jms.943"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,11,14]]},"references-count":9,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2006,1]]}},"alternative-id":["10.1002\/jms.943"],"URL":"https:\/\/doi.org\/10.1002\/jms.943","archive":["Portico"],"relation":{},"ISSN":["1076-5174","1096-9888"],"issn-type":[{"value":"1076-5174","type":"print"},{"value":"1096-9888","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,11,14]]}}}