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The most predominant strains were found to be divergent genotype\/subtype F\/<jats:italic>adw4<\/jats:italic> strains (66.6%), followed by A\/<jats:italic>adw2<\/jats:italic> (20.0%), D\/<jats:italic>ayw3<\/jats:italic> (6.7%), and G\/<jats:italic>adw2<\/jats:italic> (6.7%). The S\u2010genes of the Mexican genotype F strains and two Nicaraguan strains described previously formed a subcluster with more than 4% divergence from the other strains within this genotype. The Mexican strains within genotypes A and D showed the highest homology with strains from Europe and the United States. Ten amino acid substitutions not described previously were found in the S\u2010genes of strains from nine chronic carriers, whereas the S gene in strains from six acute hepatitis B patients were highly conserved as compared to their respective genotypes. One genotype F strain from an HBsAg positive chronic carrier had a T to A mutation at position 647, forming a translational stop at codon 216. Two genotype F strains from HBsAg negative chronic carriers had a Val180 instead of an Ala found in the other genotype F strains. This study shows that a divergent genotype F predominates in Mexican strains analyzed, which presented amino acid substitutions not reported previously outside the <jats:italic>a<\/jats:italic> determinant. J. Med. Virol. 68:24\u201332, 2002. \u00a9 2002 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jmv.10166","type":"journal-article","created":{"date-parts":[[2002,10,6]],"date-time":"2002-10-06T11:53:08Z","timestamp":1033905188000},"page":"24-32","source":"Crossref","is-referenced-by-count":67,"title":["Genotypes and S\u2010gene variability of Mexican hepatitis B virus 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