{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T09:03:36Z","timestamp":1784192616234,"version":"3.55.0"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2002,7,24]],"date-time":"2002-07-24T00:00:00Z","timestamp":1027468800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2002,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A human leukocyte antigen (HLA)\u2010matched unrelated bone marrow transplantation (BMT) was performed in a 13\u2010year\u2010old patient with the congenital immunodeficiency syndrome, Wiskott\u2010Aldrich syndrome. The patient had a history of acyclovir (ACV)\u2010resistant (ACV<jats:sup>r<\/jats:sup>) herpes simplex virus type 1 (HSV\u20101) infections prior to BMT. After BMT, the skin lesions caused by HSV\u20101 relapsed on the face and genito\u2010anal areas. Ganciclovir (GCV) therapy was initiated, but the mucocutaneous lesions worsened. An HSV\u20101 isolate recovered from the lesions during this episode was resistant to both ACV and GCV. The ACV<jats:sup>r<\/jats:sup> isolate was confirmed to have the same mutation in the viral thymidine kinase (TK) gene as that of the previously isolated ACV<jats:sup>r<\/jats:sup> isolates from the patient. After treatment switch to foscarnet (PFA), there was a satisfactory remission but not a complete recovery. Although the mucocutaneous lesions improved, a PFA\u2010resistant (PFA<jats:sup>r<\/jats:sup>) HSV\u20101 was isolated 1 month after the start of PFA therapy. The PFA<jats:sup>r<\/jats:sup> HSV\u20101 isolate coded for the same mutation in the viral TK gene as the ACV<jats:sup>r<\/jats:sup> HSV\u20101 isolates. Furthermore, the PFA<jats:sup>r<\/jats:sup> isolate also expressed a mutated viral DNA polymerase (DNA pol) with an amino acid (Gly) substitution for Val at position 715. This is the first report on the clinical course of a BMT\u2010associated ACV<jats:sup>r<\/jats:sup> HSV\u20101 infection that subsequently developed resistance to foscarnet as well. J. Med. Virol. 68:99\u2013104, 2002. \u00a9 2002 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jmv.10175","type":"journal-article","created":{"date-parts":[[2002,10,6]],"date-time":"2002-10-06T11:53:08Z","timestamp":1033905188000},"page":"99-104","source":"Crossref","is-referenced-by-count":30,"title":["Bone marrow transplantation in a child with Wiskott\u2010Aldrich syndrome latently infected with acyclovir\u2010resistant (ACV<sup>r<\/sup>) herpes simplex virus type 1: Emergence of foscarnet\u2010resistant virus originating from the ACV<sup>r<\/sup> 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