{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T04:52:15Z","timestamp":1778215935147,"version":"3.51.4"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2002,7,24]],"date-time":"2002-07-24T00:00:00Z","timestamp":1027468800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2002,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A very high annual incidence of 56 per million population below the age of 20 years for subacute sclerosing panencephalitis (SSPE) has been reported from Papua New Guinea (PNG). In a more recent study, we have confirmed this unusual high incidence for Eastern Highlands Province (EHP) of PNG. In the study, it was observed that the vaccination rate among SSPE patients registered at Goroka Base General Hospital (GBGH) in EHP was higher than that of other infants in the province in recent years. To identify the measles virus (MV) responsible for SSPE in EHP, sequence analysis of hypervariable region of the N gene was performed from 13 MV genomes: 2 amplified from clinical specimens of SSPE patients and 11 from acute measles patients. In 2 cases among the 11 with acute measles, nucleotide sequence of the entire H gene derived from isolated viruses was determined. Both nucleotide sequence and phylogenetic tree analyses showed that the amplified MV cDNAs were closely related to one another and belonged to the D3 genotype though they were different from any previously reported MV sequences. No genome sequences of vaccine strains were detected. These findings suggest that the MV strains prevailing in the highlands of PNG belong to genotype D3 of the MV and this wild\u2010type MV rather than the vaccine strains was likely to be responsible for SSPE in these patients. J. Med. Virol. 68:105\u2013112, 2002. \u00a9 2002 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jmv.10176","type":"journal-article","created":{"date-parts":[[2002,10,6]],"date-time":"2002-10-06T11:53:08Z","timestamp":1033905188000},"page":"105-112","source":"Crossref","is-referenced-by-count":28,"title":["Molecular analysis of measles virus genome derived from SSPE and acute measles patients in Papua, New Guinea"],"prefix":"10.1002","volume":"68","author":[{"given":"Kenji","family":"Miki","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsuhiro","family":"Komase","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles S.","family":"Mgone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryuta","family":"Kawanishi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masumi","family":"Iijima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joyce M.","family":"Mgone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter G.","family":"Asuo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael P.","family":"Alpers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiaki","family":"Takasu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomohiko","family":"Mizutani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2002,7,24]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"141","article-title":"Vaccine in the national immunization programme","volume":"36","author":"Bass AG","year":"1993","journal-title":"PNG Med J"},{"key":"e_1_2_1_3_1","first-page":"585","article-title":"Subacute sclerosing panencephalitis surveillance","volume":"31","author":"CDC","year":"1982","journal-title":"MMWR Weekly"},{"key":"e_1_2_1_4_1","first-page":"6","article-title":"A review of measles admissions and deaths in the paediatric ward of Goroka Base Hospital during 1989","volume":"34","author":"Coakley KJ","year":"1991","journal-title":"PNG Med J"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0733-8619(18)31062-4"},{"key":"e_1_2_1_6_1","first-page":"1267","volume-title":"Fields Virology","author":"Griffin DE","year":"1996"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.220.7.959"},{"key":"e_1_2_1_8_1","first-page":"493","article-title":"SSPE: clinical staging, course and frequency, abstracted","volume":"32","author":"Jabbour JT","year":"1975","journal-title":"Arch Neurol"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-78-6-1287"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268800050044"},{"key":"e_1_2_1_11_1","first-page":"91","article-title":"Contral measures and outcome of the measles epidemic of 1999 in Eastern Highlands Province","volume":"43","author":"Mgone JM","year":"2000","journal-title":"PNG Med J"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0168-1702(94)00074-M"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/18.3.684"},{"key":"e_1_2_1_14_1","volume-title":"The National Health Plan, 1986\u20131990","author":"Papua New Guinea Department of Health","year":"1986"},{"key":"e_1_2_1_15_1","volume-title":"The National Health Plan, 1991\u20131995","author":"Papua New Guinea Department of Health","year":"1991"},{"key":"e_1_2_1_16_1","volume-title":"The National Health Plan, 1996\u20132000","author":"Papua New Guinea Department of Health","year":"1996"},{"key":"e_1_2_1_17_1","volume-title":"Routine immunization results for 1990\u20131998","author":"Papua New Guinea Department of Health Promotive and Preventive Health Services","year":"1998"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-76-5-1173"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-78-1-97"},{"key":"e_1_2_1_20_1","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1093\/oxfordjournals.aje.a112206","article-title":"Subacute sclerosing panencephalitis: an epidemiological study in Israel","volume":"103","author":"Soffer D","year":"1976","journal-title":"Am J Epidemiol"},{"key":"e_1_2_1_21_1","unstructured":"TakasuT MgoneJM MgoneCS MikiK KomaseK NamaeH KokubunY NishimuraT MarcusJ AsuoP AlpersMP.1998.A continuing high incidence of sub\u2010acute sclerosing panencephalitis (SSPE) in the Eastern Highlands of Papua New Guinea. Abstracts of the Medical Societyof Papua New Guinea. 34th Annual Medical Symposium 7\u201311 September. p 41\u201342 (Abstract)."},{"key":"e_1_2_1_22_1","unstructured":"TakasuT KomaseK MikiK KawanishiR MgoneCS AlpersMP MgoneJM MarcusJ AsuoGP.1999.Subacute sclerosing panencephalitis (SSPE) in Papua New Guinea (PNG): epidemiology and virus analysis. Part 1 Characteristics of measles immunization age at measles length of incubation period and age at SSPE onset among SSPE patients and characteristics of age at measles among measles patients in Goroka area Eastern Highlands Province. Annual Report of the Slow Virus Infection Research Committee The Ministry of Health and Welfare of Japan (Chairman: Kitamoto T.) p 38\u201343 (in Japanese with English Abstract)."},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-72-1-83"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/22.22.4673"},{"key":"e_1_2_1_25_1","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1128\/JCM.37.3.775-777.1999","article-title":"Case report and molecular analysis of subacute sclerosing panencephalitis in a South African Child","volume":"37","author":"Vardas E","year":"1999","journal-title":"J Clin Microbio"},{"key":"e_1_2_1_26_1","first-page":"242","article-title":"Standardization of nomenclature for describing the genetic characteristics of the wild\u2010type measles viruses","volume":"76","author":"World Health Organization","year":"2001","journal-title":"Wkly Epidemiol Rec"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9071(199705)52:1<113::AID-JMV18>3.0.CO;2-N"}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjmv.10176","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.10176","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,18]],"date-time":"2023-11-18T00:00:34Z","timestamp":1700265634000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.10176"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,7,24]]},"references-count":26,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2002,9]]}},"alternative-id":["10.1002\/jmv.10176"],"URL":"https:\/\/doi.org\/10.1002\/jmv.10176","archive":["Portico"],"relation":{},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"value":"0146-6615","type":"print"},{"value":"1096-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,7,24]]}}}