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Consecutive blood samples from 29 dengue patients, of whom 21 had dengue fever and 8 had dengue hemorrhagic fever\/dengue shock syndrome, were collected, and the immunophenotypes of the peripheral blood mononuclear cells were determined by flow cytometry. The early activation marker CD69 appeared on lymphocytes and monocytes at day 4 after the onset of fever, and declined afterward. However, a transient reverse in the CD4\/CD8 ratio occurred at days 6\u201310 after the onset of fever. The CD4\/CD8 ratio inversion was manifested in 10 of 29 dengue patients and was encountered more frequently in dengue hemorrhagic fever\/dengue shock syndrome than in dengue fever patients. Analysis of the clinical blood cell count of these 10 cases showed that increase of immature neutrophils developed at fever days 5\u20136, CD4<jats:sup>dim<\/jats:sup> or CD8<jats:sup>dim<\/jats:sup> monocytosis at days 6\u20137, and atypical lymphocytosis at days 8\u201310 after the onset of fever. Serum IL\u20106 was found at either day 7 or day 9\u201311. The PHA\u2010stimulated T\u2010cell response was depressed as well. These changes in immune parameters indicate aberrant immune activation during dengue virus infection and might be involved in the pathogenesis of dengue virus infection. J. Med. Virol. 68: 241\u2013252, 2002. \u00a9 2002 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jmv.10198","type":"journal-article","created":{"date-parts":[[2002,10,6]],"date-time":"2002-10-06T12:12:48Z","timestamp":1033906368000},"page":"241-252","source":"Crossref","is-referenced-by-count":32,"title":["Transient CD4\/CD8 ratio inversion and aberrant immune activation during dengue virus infection"],"prefix":"10.1002","volume":"68","author":[{"given":"Ching\u2010Chuan","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kao\u2010Jean","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yee\u2010Shin","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Trai\u2010Ming","family":"Yeh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsiao\u2010Sheng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huan\u2010Yao","family":"Lei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2002,8,12]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0966-842X(97)01126-8"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.17.1.189"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-58-1-37"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-2478(81)90088-2"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1958.7.561"},{"key":"e_1_2_1_7_1","doi-asserted-by":"crossref","first-page":"3623","DOI":"10.1128\/JVI.73.5.3623-3629.1999","article-title":"Bystander target cell lysis and cytokine production by dengue virus\u2010specific human CD4+ cytotoxic T\u2010lymphocyte clones","volume":"73","author":"Gagnon SJ","year":"1999","journal-title":"J Virol"},{"key":"e_1_2_1_8_1","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1128\/jcm.17.4.672-676.1983","article-title":"Cold\u2010reactive immunoglobulin M antilymphocyte antibodies directed against B cells in Thai children with dengue hemorrhagic fever","volume":"17","author":"Gilbreath MJ","year":"1983","journal-title":"J Clin Microbiol"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1086\/315072"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1086\/314680"},{"key":"e_1_2_1_11_1","first-page":"350","article-title":"Observations related to pathogenesis of dengue hemorrhagic fever. 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