{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T06:17:03Z","timestamp":1759990623003},"reference-count":12,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2002,8,12]],"date-time":"2002-08-12T00:00:00Z","timestamp":1029110400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2002,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Primary cytomegalovirus (CMV) infection with marked constitutional symptoms is rare in immunocompetent individuals and in those with iatrogenic immunosuppression, except transplant recipients. Four patients admitted to hospital with clinical illnesses associated with primary CMV infection were identified over a 12\u2010month period. Their medical records were reviewed with regard to clinical and laboratory data, and outcome. Primary CMV infection was defined by the concomitant presence of CMV IgM and low avidity CMV IgG antibody. Of two patients with no known underlying illness, one presented with thrombocytopenic purpura and the other with vasculitis. Two patients receiving immunosuppressants for underlying ulcerative colitis presented with CMV\u2010induced pancytopenia and CMV colitis. Atypical lymphocytosis was a feature on blood film examination in three of the four cases. One patient with disseminated CMV infection died of progressive multiorgan failure despite antiviral treatment. CMV disease following primary CMV infection should be considered in otherwise immunocompetent individuals with atypical lymphocytosis on blood film analysis, and particularly in patients on immunosuppressants such as those with ulcerative colitis, since early diagnosis and treatment with antiviral drugs may improve outcome. J. 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Virol. 68: 237\u2013240, 2002. \u00a9 2002 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jmv.10200","type":"journal-article","created":{"date-parts":[[2002,10,6]],"date-time":"2002-10-06T12:12:48Z","timestamp":1033906368000},"page":"237-240","source":"Crossref","is-referenced-by-count":8,"title":["Unusual manifestations of primary cytomegalovirus infection in patients without HIV infection and without organ transplants"],"prefix":"10.1002","volume":"68","author":[{"given":"Brendan","family":"Crowley","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jed","family":"Dempsey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ade","family":"Olujohungbe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdul","family":"Khan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken","family":"Mutton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.A.","family":"Hart","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2002,8,12]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"2493","volume-title":"Virology","author":"Alford CA","year":"1996"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1128\/CDLI.8.2.429-431.2001","article-title":"Multicenter evaluation of a rapid and convenient method for determination of cytomegalovirus immunoglobulin G avidity","volume":"3","author":"Baccard\u2010Longere M","year":"2001","journal-title":"Clin Diag Lab Immunol"},{"key":"e_1_2_1_4_1","first-page":"1046","article-title":"Cytomegalovirus infection of the gastrointestinal tract in patients without AIDS","volume":"22","author":"Buckner FS","year":"1996","journal-title":"Clin Infect Dis"},{"key":"e_1_2_1_5_1","first-page":"1351","volume-title":"Principles and practice of infectious diseases","author":"Crumpacker CS","year":"2000"},{"key":"e_1_2_1_6_1","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1182\/blood.V76.5.1046.1046","article-title":"\u03b3\u2010Interferon and tumor necrosis factor production after bone marrow transplantation is augmented by exposure to marrow fibroblast infected with cytomegalovirus","volume":"76","author":"Duncombe AS","year":"1990","journal-title":"Blood"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/24.1.52"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-199409000-00003"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-200106150-00021"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1086\/318449"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1086\/520307"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119871"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.45.11.1037"}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjmv.10200","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.10200","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,18]],"date-time":"2023-11-18T08:27:31Z","timestamp":1700296051000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.10200"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,8,12]]},"references-count":12,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2002,10]]}},"alternative-id":["10.1002\/jmv.10200"],"URL":"https:\/\/doi.org\/10.1002\/jmv.10200","archive":["Portico"],"relation":{},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"value":"0146-6615","type":"print"},{"value":"1096-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,8,12]]}}}