{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T08:38:54Z","timestamp":1772527134915,"version":"3.50.1"},"reference-count":37,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2001,4,30]],"date-time":"2001-04-30T00:00:00Z","timestamp":988588800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2001,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The aim of this study was to clinically characterize young patients with hepatitis\u2010C\u2010related cirrhosis. We compared 27 patients with liver cirrhosis (Group LC) who were anti\u2010HCV positive, aged 40 years or less at the time of diagnosis, with 323 consecutive patients with HCV\u2010related chronic hepatitis (Group CH) matched for age and gender. Furthermore, Group LC was divided into two arbitrary groups (29\u201335 years, n\u2009=\u20098 \/36\u201340 years, n\u2009=\u200919), based on the age of patients at the time of diagnosis of liver cirrhosis. Patients' characteristics and family history were investigated, and the frequency of transporter associated with antigen processing 2 (TAP2) was determined. A family history of liver disease was present in 40.7% of Group LC but in 18.0% of Group CH (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). The younger the age of diagnosis of cirrhosis in Group LC, the higher the frequency of a positive family history (29\u201335 years, 87.5%; 36\u201340 years, 21.1%, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). The frequency of TAP2*0201 was significantly higher in young adult patients with HCV\u2010related liver cirrhosis than in HCV carriers with normal ALT (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05), and tended to be higher than in uninfected normal subjects (<jats:italic>P<\/jats:italic>\u2009=\u20090.05). The cumulative survival rate of cirrhosis patients with family history of liver diseases was significantly lower than that of cirrhosis patients without such history (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). Our findings suggest that a positive family history of liver disease and TAP2*0201 polymorphism may be risk factors for HCV\u2010related liver cirrhosis in young adults. J. Med. Virol. 64:109\u2013116, 2001. \u00a9 2001 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jmv.1025","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T22:08:54Z","timestamp":1030313334000},"page":"109-116","source":"Crossref","is-referenced-by-count":27,"title":["Risk factors of hepatitis C virus\u2010related liver cirrhosis in young adults: Positive family history of liver disease and transporter associated with antigen processing 2 (TAP2) *0201 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