{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:50:58Z","timestamp":1788871858407,"version":"build-2803163510"},"reference-count":53,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2003,2,24]],"date-time":"2003-02-24T00:00:00Z","timestamp":1046044800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002923","name":"CONICET","doi-asserted-by":"crossref","award":["PIP 675\/98"],"award-info":[{"award-number":["PIP 675\/98"]}],"id":[{"id":"10.13039\/501100002923","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Mosoteguy Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2003,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Cervical carcinoma is the leading cause of cancer death in Quechua indians from Jujuy (northwestern Argentina). To determine the prevalence of HPV\u201016 variants, 106 HPV\u201016 positive cervical samples were studied, including 33 low\u2010grade squamous intraepithelial lesions (LSIL), 28 high\u2010grade squamous intraepithelial lesions (HSIL), 9 invasive cervical cancer (ICC), and 36 samples from women with normal colposcopy and cytology. HPV genome variability was examined in the L1 and E6 genes by PCR\u2010hybridization. In a subset of 20 samples, a LCR fragment was also analyzed by PCR\u2010sequencing. Most variants belonged to the European branch with subtle differences that depended on the viral gene fragment studied. Only about 10% of the specimens had non\u2010European variants, including eight Asian\u2010American, two Asian, and one North\u2010American\u20101. E6 gene analysis revealed that 43% of the samples were identical to HPV\u201016 prototype, while 57% corresponded to variants. Interestingly, the majority (87%) of normal smears had HPV\u201016 prototype, whereas variants were detected mainly in SIL and ICC. LCR sequencing yielded 80% of variants, including 69% of European, 19% Asian\u2010American, and 12% Asian. We identified a new variant, the Argentine Quechua\u201051 (AQ\u201051), similar to B\u201014 plus two additional changes: G7842\u2192A and A7837\u2192C; phylogenetic inference allocated it in the Asian\u2010American branch. The high proportion of European variants may reflect Spanish colonial influence on these native Inca descendants. The predominance of HPV\u201016 variants in pathologic samples when compared to normal controls could have implications for the natural history of cervical lesions. J. Med. Virol. 69:546\u2013552, 2003. \u00a9 2003 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jmv.10343","type":"journal-article","created":{"date-parts":[[2003,2,25]],"date-time":"2003-02-25T09:03:37Z","timestamp":1046163817000},"page":"546-552","source":"Crossref","is-referenced-by-count":44,"title":["Human papillomavirus type\u201016 variants in Quechua aboriginals from Argentina"],"prefix":"10.1002","volume":"69","author":[{"given":"Mar\u00eda Alejandra","family":"Picconi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lidia Virginia","family":"Alonio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Sichero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viviana","family":"Mbayed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luisa Lina","family":"Villa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Gronda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodolfo","family":"Campos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ang\u00e9lica","family":"Teyssi\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2003,2,24]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1054\/bjoc.2000.1247"},{"key":"e_1_2_1_3_1","first-page":"33","article-title":"Evolution of Papillomaviruses","volume":"186","author":"Bernard HU","year":"1994","journal-title":"Curr Top Microbiol Immunol"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/170.5.1077"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19981005)78:2<166::AID-IJC8>3.0.CO;2-X"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/87.11.796"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.55.4.244"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1006\/scbi.1999.0147"},{"key":"e_1_2_1_9_1","doi-asserted-by":"crossref","first-page":"2057","DOI":"10.1128\/jvi.66.4.2057-2066.1992","article-title":"Molecular variants of human papillomavirus type 16 from four continents suggest ancient pandemic spread of the virus and its coevolution with humankind","volume":"66","author":"Chan S\u2010Y","year":"1992","journal-title":"J Virol"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/172.6.1584"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-76-4-1057"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-78487-3_1"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm0595-464"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.1998.5231"},{"key":"e_1_2_1_15_1","unstructured":"FelsensteinJ.1993.PHYLIP: phylogeny inference package (version 3.5c). 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