{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T06:42:47Z","timestamp":1793256167308,"version":"4.5.0"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2003,3,4]],"date-time":"2003-03-04T00:00:00Z","timestamp":1046736000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2003,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The kinetics of total and dengue virus\u2010specific immunoglobulin E (IgE) were studied in serial serum samples obtained from 168 patients, 41 of whom suffered from primary dengue virus infection and 127 suffered from secondary dengue virus infection. Seventy\u2010one patients were classified as dengue fever, 30 as dengue hemorrhagic fever, and 67 as dengue shock syndrome. A control group included single serum samples from patients with a herpes virus infection (n\u2009=\u200914), non\u2010dengue febrile patients (n\u2009=\u200910), and healthy blood donors (n\u2009=\u200910). Patients with dengue virus infection had higher levels of total and dengue virus\u2010specific IgE than non\u2010dengue patients (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). Patients with secondary dengue virus infections had not significantly increased levels of both total and dengue virus\u2010specific IgE in the acute phase of disease compared to patients with primary dengue virus infections. Dengue virus\u2010specific IgE was significantly higher in dengue hemorrhagic fever and\/or dengue shock syndrome patients compared to dengue fever and non\u2010dengue patients (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). In conclusion, this study showed elevated total and dengue virus\u2010specific IgE serum antibody levels in the acute stage of disease. Therefore, measurement of both total and dengue virus\u2010specific IgE serum antibodies can be used as an additional prognostic marker in the development of severe complications in dengue virus infections. In addition, the presence and increase of dengue virus\u2010specific IgE serum antibodies in patients with dengue virus infections is suggestive of the pathogenetic role that IgE may play in the hemostatic disorders observed in dengue hemorrhagic fever and dengue shock syndrome. J. Med. Virol. 70:91\u201398, 2003. \u00a9 2003 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jmv.10358","type":"journal-article","created":{"date-parts":[[2003,3,18]],"date-time":"2003-03-18T22:41:17Z","timestamp":1048027277000},"page":"91-98","source":"Crossref","is-referenced-by-count":61,"title":["Elevated levels of total and dengue virus\u2010specific immunoglobulin E in patients with varying disease severity"],"prefix":"10.1002","volume":"70","author":[{"given":"Penelopie","family":"Koraka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernadette","family":"Murgue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Deparis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatty E.","family":"Setiati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catarina","family":"Suharti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric C.M.","family":"van Gorp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.E.","family":"Hack","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert D.M.E","family":"Osterhaus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Groen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2003,3,4]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1128\/cdli.1.3.269-272.1994","article-title":"Elevated levels of total and Puumala virus\u2010specific immunoglobulin E in the Scandinavian type of hemorrhagic fever with renal syndrome","volume":"1","author":"Alexeyev OA","year":"1994","journal-title":"Clin Diagn Lab Immunol"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000233507"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0966-842X(97)01126-8"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199106203242506"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.188.6.1135"},{"key":"e_1_2_1_7_1","doi-asserted-by":"crossref","first-page":"63","DOI":"10.4049\/jimmunol.146.1.63","article-title":"IgE\u2010dependent cytokine production by human peripheral blood mononuclear phagocytes","volume":"146","author":"Borish L","year":"1991","journal-title":"J Immunol"},{"key":"e_1_2_1_8_1","doi-asserted-by":"crossref","first-page":"4162","DOI":"10.4049\/jimmunol.155.9.4162","article-title":"IL\u20104 induces human B cell maturation and IgE synthesis in SCID\u2010hu mice: inhibition of ongoing IgE production by in vivo treatment with an IL\u2010 4\/IL\u201013 receptor antagonist","volume":"155","author":"Carballido JM","year":"1995","journal-title":"J Immunol"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-695X.2000.tb01474.x"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3156.1998.00319.x"},{"key":"e_1_2_1_11_1","doi-asserted-by":"crossref","first-page":"8","DOI":"10.4049\/jimmunol.147.1.8","article-title":"Anti\u2010CD40 monoclonal antibodies or CD4+ T cell clones and IL\u20104 induce IgG4 and IgE switching in purified human B cells via different signaling pathways","volume":"147","author":"Gascan H","year":"1991","journal-title":"J Immunol"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1999.61.412"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2000.63.5"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0966-842X(99)01669-8"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.39.12.4332-4338.2001"},{"key":"e_1_2_1_16_1","first-page":"273","volume-title":"Dengue and Dengue haemorrhagic fever","author":"Kurane I","year":"1997"},{"key":"e_1_2_1_17_1","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1128\/CDLI.6.4.624-626.1999","article-title":"Total immunoglobulin E levels and dengue infection on San Andres Island, Colombia","volume":"6","author":"Miguez\u2010Burbano MJ","year":"1999","journal-title":"Clin Diagn Lab Immunol"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(96)80606-2"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1086\/516486"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3156.1999.00478.x"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/11.Supplement_4.S854"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/2.1.142"},{"key":"e_1_2_1_23_1","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1128\/iai.28.1.290-291.1980","article-title":"Immunoglobulin E in patients with Japanese encephalitis","volume":"28","author":"Pavri KM","year":"1980","journal-title":"Infect Immunol"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.8.3730"},{"key":"e_1_2_1_25_1","first-page":"245","volume-title":"Dengue and Dengue haemorrhagic fever","author":"Rothman AL","year":"1997"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1053\/beha.2000.0073"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166-0934(87)90053-X"},{"key":"e_1_2_1_28_1","volume-title":"Dengue hemorrhagic fever: diagnosis, treatment, prevention and control","author":"World Health Organization","year":"1997"},{"key":"e_1_2_1_29_1","unstructured":"World Health Organization.1999.Strengthening implementation of the global strategy for Dengue\/Dengue Hemorrhagic Fever prevention and control. Report of the informal consultation October 1999."}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjmv.10358","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.10358","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T15:35:37Z","timestamp":1700235337000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.10358"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,3,4]]},"references-count":28,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2003,5]]}},"alternative-id":["10.1002\/jmv.10358"],"URL":"https:\/\/doi.org\/10.1002\/jmv.10358","archive":["Portico"],"relation":{},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"value":"0146-6615","type":"print"},{"value":"1096-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,3,4]]}}}