{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T09:05:06Z","timestamp":1789549506628,"version":"build-2803163510"},"reference-count":12,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2003,4,9]],"date-time":"2003-04-09T00:00:00Z","timestamp":1049846400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2003,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The spectrum of antibodies against Epstein\u2010Barr virus nuclear antigen\u20101 (EBNA\u20101) in patients with a recent history of infectious mononucleosis and nonaffected EBV\u2010positive individuals has been characterized by epitope mapping. Sera were evaluated for antibodies to all unique maximally overlapping octapeptides of EBNA\u20101. Both normal controls and patients with infectious mononucleosis produce IgG antibodies that recognize the glycine\u2010alanine\u2010rich portion of EBNA\u20101, as previously described. All EBNA\u20101 IgG\u2010positive infectious mononucleosis patients tested, however, consistently produce IgG specific for an additional epitope (aa 398\u2013412 PPPGRRPFFHPVGEA) near the middle of the EBNA\u20101 protein. This region was not found to be antigenic in healthy EBV\u2010seropositive individuals. This region does, however, cross\u2010react with the sequence PPPGMRPP from the common lupus spliceosomal autoantigen Sm B\u2032 in several infectious mononucleosis patient sera. Patients with recent clinical infectious mononucleosis temporarily recognize a unique cross\u2010reactive epitope of EBNA\u20101 not bound by antibodies from non\u2010infectious mononucleosis EBV\u2010positive sera or those with a distant history of IM. J. Med. Virol. 70: 253\u2013257, 2003. \u00a9 2003 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jmv.10385","type":"journal-article","created":{"date-parts":[[2003,4,10]],"date-time":"2003-04-10T10:01:57Z","timestamp":1049968917000},"page":"253-257","source":"Crossref","is-referenced-by-count":50,"title":["Infectious mononucleosis patients temporarily recognize a unique, cross\u2010reactive epitope of Epstein\u2010Barr virus nuclear antigen\u20101"],"prefix":"10.1002","volume":"70","author":[{"given":"Micah T.","family":"McClain","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin C.","family":"Rapp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John B.","family":"Harley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith A.","family":"James","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2003,4,9]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1006\/jaut.1998.0227"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.286.24.3083"},{"key":"e_1_2_1_4_1","doi-asserted-by":"crossref","first-page":"2180","DOI":"10.1128\/jcm.29.10.2180-2186.1991","article-title":"Epstein\u2010Barr virus nuclear antigen 1 linear epitopes that are reactive with immunoglobulin A (IgA) or IgG in sera from nasopharyngeal carcinoma patients or from healthy donors","volume":"29","author":"Cheng HM","year":"1991","journal-title":"J Clin Microbiol"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/130.3.231"},{"key":"e_1_2_1_6_1","doi-asserted-by":"crossref","first-page":"2074","DOI":"10.4049\/jimmunol.148.7.2074","article-title":"Linear epitope mapping of an Sm B\/B\u2032 polypeptide","volume":"148","author":"James JA","year":"1992","journal-title":"J Immunol"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/375685a0"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.168.4.2054"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780330711"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.165.4.1026"},{"key":"e_1_2_1_11_1","doi-asserted-by":"crossref","first-page":"593","DOI":"10.4049\/jimmunol.138.2.593","article-title":"The glycine\u2010alanine repeating region is the major epitope of the Epstein\u2010Barr Nuclear Antigen\u20101 (EBNA\u20101)","volume":"138","author":"Rumpold H","year":"1987","journal-title":"J Immunol"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI117782"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI117781"}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjmv.10385","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.10385","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,18]],"date-time":"2023-11-18T02:58:24Z","timestamp":1700276304000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.10385"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,4,9]]},"references-count":12,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2003,6]]}},"alternative-id":["10.1002\/jmv.10385"],"URL":"https:\/\/doi.org\/10.1002\/jmv.10385","archive":["Portico"],"relation":{},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"value":"0146-6615","type":"print"},{"value":"1096-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,4,9]]}}}