{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T22:24:54Z","timestamp":1787955894867,"version":"build-2784847793"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2003,6,2]],"date-time":"2003-06-02T00:00:00Z","timestamp":1054512000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2003,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Dengue hemorrhagic fever and dengue shock syndrome (DHF\/DSS) are severe complications of dengue virus (DV) infection. However, the pathogenesis of hemorrhage induced by dengue virus infection is poorly understood. Since endothelial cells play a pivotal role in the regulation of hemostasis, we studied the effect of DV infection on the production of tissue plasminogen activator (tPA) and plasminogen activator inhibitor 1 (PAI\u20101) in vitro using both primary isolated endothelial cells, human umbilical cord veins cells, and a human microvascular endothelial cell line. DV infection significantly induced the secretion of tPA but not PAI\u20101 of human endothelial cells. In addition, tPA mRNA of endothelial cells was induced by DV as demonstrated by RT\u2010PCR. Antibody against IL\u20106 but not control antibody inhibited DV\u2010induced tPA production of endothelial cells. Furthermore, a good correlation between sera levels of IL\u20106 and tPA was found in DHF but not DF patients. These results suggest that IL\u20106 can regulate DV\u2010induced tPA production of endothelial cells, which may play important roles in the pathogenic development of DHF\/DSS. J. Med. 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