{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T10:36:16Z","timestamp":1791196576663,"version":"4.1.0"},"reference-count":18,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2003,9,4]],"date-time":"2003-09-04T00:00:00Z","timestamp":1062633600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2003,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Epstein\u2010Barr virus (EBV) is an important pathogen in human immunodeficiency virus (HIV)\u2010infected individuals that causes lymphoma and other lymphoproliferative disorders upon disease progression; however, interaction between the two viruses during acute infection is not well known. Expression of CCR5, a major coreceptor for HIV, was enhanced on CD4<jats:sup>+<\/jats:sup> T cells from patients with acute EBV infection. Furthermore, susceptibility of those cells to R5\u2010HIV\u20101, but not X4\u2010HIV\u20101, was increased. EBV effects on CCR5 expression on or susceptibility to R5\u2010HIV\u20101 of CD4<jats:sup>+<\/jats:sup> T cells did not require coinfection of the same cell with the two viruses, because CD4<jats:sup>+<\/jats:sup> T cells from patients with acute EBV infection were not infected with EBV. Considering that both HIV and EBV are transmitted by intimate contact, such possible interaction between the two viruses may have implications for viral transmission and the pathogenesis of HIV disease. J. Med. Virol. 71:343\u2013346, 2003. \u00a9 2003 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jmv.10494","type":"journal-article","created":{"date-parts":[[2003,9,5]],"date-time":"2003-09-05T14:44:33Z","timestamp":1062773073000},"page":"343-346","source":"Crossref","is-referenced-by-count":11,"title":["Increased susceptibility to HIV\u20101 of peripheral blood lymphocytes in acute infection with Epstein\u2010Barr virus"],"prefix":"10.1002","volume":"71","author":[{"given":"Masako","family":"Moriuchi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Moriuchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2003,9,4]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0966-842X(97)01089-5"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.187.1.129"},{"key":"e_1_2_1_4_1","doi-asserted-by":"crossref","first-page":"2649","DOI":"10.1182\/blood.V96.8.2649","article-title":"Up\u2010regulation of HIV coreceptors CXCR4 and CCR5 on CD4+ T cells during human endotoxemia and after stimulation with (myco)bacterial antigens: the role of cytokines","volume":"96","author":"Juffermans NP","year":"2000","journal-title":"Blood"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M008391200"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M204980200"},{"key":"e_1_2_1_7_1","doi-asserted-by":"crossref","first-page":"5441","DOI":"10.4049\/jimmunol.159.11.5441","article-title":"Cloning and analysis of the promoter region of CCR5, a coreceptor for HIV\u20101 entry","volume":"159","author":"Moriuchi H","year":"1997","journal-title":"J Immunol"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI4151"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.187.10.1689"},{"key":"e_1_2_1_10_1","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1182\/blood.V93.4.1433","article-title":"GATA\u20101 transcription factor transactivates the promoter for CCR5, a co\u2010receptor for HIV\u20101 entry","volume":"93","author":"Moriuchi M","year":"1999","journal-title":"Blood"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1086\/315496"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1006\/viro.2000.0667"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1006\/clim.1999.4713"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-200109070-00004"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.67.5.2853-2861.1993"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1086\/319248"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.185.9.1681"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1086\/318827"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.8356453"}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjmv.10494","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.10494","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,7]],"date-time":"2023-10-07T20:23:09Z","timestamp":1696710189000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.10494"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,9,4]]},"references-count":18,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2003,11]]}},"alternative-id":["10.1002\/jmv.10494"],"URL":"https:\/\/doi.org\/10.1002\/jmv.10494","archive":["Portico"],"relation":{},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"value":"0146-6615","type":"print"},{"value":"1096-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,9,4]]}}}