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Different wildlife species act as reservoir hosts with ixodid tick species as vectors. TBE virus (TBEV) causes 40\u2013130 cases confirmed serologically in Sweden each year. Characteristics of TBEV strains circulating in Sweden have not been investigated previously and no viral sequence data has been reported. In the present study, virus strains were isolated from serum of patients with clinical symptoms consistent with acute TBEV infection. Serologic characterisation, using a panel of E\u2010specific monoclonal antibodies and cross\u2010neutralisation tests, indicated that the Swedish strains of TBEV, isolated 1958\u20131994, all belonged to the Western TBEV subtype, which includes the Austrian vaccine strain Neudoerfl. Genetic analysis of a partial E\u2010sequence confirmed this close relationship: all Swedish TBEV strains belonged to the European lineage of the Western TBEV subtype, which includes the previously characterised strains Neudoerfl, Hypr, and Kumlinge. Further, three Swedish strains showed partial E\u2010sequences identical to that of the Finnish Kumlinge strain, ten Swedish strains formed a well\u2010supported separate cluster, whereas four others did not show any real clustering. No apparent correlation was observed in comparison of clinical parameters with genetic data or geographic origin of the strains. J. Med. Virol. 71:610\u2013621, 2003. \u00a9 2003 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jmv.10497","type":"journal-article","created":{"date-parts":[[2003,10,8]],"date-time":"2003-10-08T08:03:23Z","timestamp":1065600203000},"page":"610-621","source":"Crossref","is-referenced-by-count":52,"title":["Characterisation of human tick\u2010borne encephalitis virus from Sweden"],"prefix":"10.1002","volume":"71","author":[{"given":"Mats","family":"Haglund","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sirkka","family":"Vene","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marianne","family":"Forsgren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00f6ran","family":"G\u00fcnther","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Johansson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Niedrig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Plyusnin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars","family":"Lindquist","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c5ke","family":"Lundkvist","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2003,10,6]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"591","article-title":"Encephalitis in immunocompetent patients due to herpes simplex virus type 1 or 2 as determined by PCR or type\u2010specific antibody assays of cerebrospinal fluid","volume":"27","author":"Aurelius E","year":"1991","journal-title":"J Med Virol"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0264-410X(98)00262-X"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0264-410X(98)00360-0"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1086\/515195"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-80-1-179"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0168-1702(93)90002-5"},{"key":"e_1_2_1_8_1","first-page":"259","article-title":"Molecular variation, evolution and geographical distribution of louping ill virus","volume":"41","author":"Gao G","year":"1997","journal-title":"Acta Virol"},{"key":"e_1_2_1_9_1","first-page":"1","article-title":"Tick\u2010borne encephalitis","volume":"33","author":"Glismann S","year":"1999","journal-title":"EPI\u2010NYT"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0168-1702(93)90082-X"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-74-2-287"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-1702(97)01451-2"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01962369"},{"key":"e_1_2_1_14_1","unstructured":"G\u00fcntherG.1997.Tick\u2010borne encephalitis\u2014on pathogenesis and prognosis (Thesis). 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