{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T15:41:05Z","timestamp":1751384465181},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2003,9,4]],"date-time":"2003-09-04T00:00:00Z","timestamp":1062633600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2003,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>During the course of acute Epstein\u2010Barr virus (EBV) infection, there is a rise of oxygen radical production. As a consequence, the production of the oxygen radical scavenger manganese superoxide dismutase (MnSOD) is increased. Patients with acute EBV infections regularly develop autoantibodies against MnSOD that are able to inhibit the enzyme activity in vitro. To elucidate the origin of the autoantibodies, the epitopes on MnSOD were determined. The entire sequence of MnSOD was synthesized as overlapping pentadecapeptides, which were scanned for their reactivity with sera of patients with acute EBV infections. Sera as well as affinity\u2010purified anti\u2010MnSOD antibodies reacted with the peptides p<jats:sup>no15<\/jats:sup> (amino acids 47\u201361) and p<jats:sup>no30<\/jats:sup> (amino acids 122\u2013136) lying in crucial parts of the MnSOD tetramer. The two main epitopes p<jats:sup>no15<\/jats:sup> and p<jats:sup>no30<\/jats:sup> showed sequence homologies with EBV\u2010encoded proteins. Reactivity of affinity\u2010purified antibodies with a peptide of the homologous BGLF4 points to a molecular mimicry causing the occurrence of anti\u2010MnSOD antibodies. Anti\u2010MnSOD antibodies were able to block the protective effects of MnSOD in a model for oxidative damage produced by xanthine\/xanthine oxidase in EAhy926 endothelial cells. Thus, these autoantibodies may contribute in vivo to the clinical symptoms by accumulation of toxic oxygen radicals. J. Med. Virol. 71:408\u2013416, 2003. \u00a9 2003 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jmv.10501","type":"journal-article","created":{"date-parts":[[2003,9,5]],"date-time":"2003-09-05T14:44:33Z","timestamp":1062773073000},"page":"408-416","source":"Crossref","is-referenced-by-count":25,"title":["Oxidative injury to endothelial cells due to Epstein\u2010Barr virus\u2010induced autoantibodies against manganese superoxide dismutase"],"prefix":"10.1002","volume":"71","author":[{"given":"Alexander 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