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Such a mathematical model is presented to simulate various cell changes of the T\u2010cell immune system during the course of HHV\u20106 infection. Model development follows several steps, beginning with a basic model containing physiological T\u2010cell pools to the introduction of infectious stimuli in the final model. A search algorithm designed to optimize the system parameters, as well as initial variables of the model, is presented. The results of simulation runs for acute HHV\u20106 infection of the final computational model correspond well to the data, as documented in human patients; they suggest that the computational model presented for the simulation of T\u2010cell levels in a given viral infection may well serve as a tool for similar studies of other viral infections, including those that lead to cellular aplasia or neoplasia. J. Med. Virol. 71:569\u2013577, 2003. \u00a9 2003 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jmv.10522","type":"journal-article","created":{"date-parts":[[2003,10,8]],"date-time":"2003-10-08T08:03:23Z","timestamp":1065600203000},"page":"569-577","source":"Crossref","is-referenced-by-count":6,"title":["Mathematical model to simulate the cellular dynamics of infection with human herpesvirus\u20106 in EBV\u2010negative infectious mononucleosis"],"prefix":"10.1002","volume":"71","author":[{"given":"Guanyu","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerhard R.F.","family":"Krueger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. 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