{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T19:15:47Z","timestamp":1793128547432,"version":"4.5.0"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,12,9]],"date-time":"2005-12-09T00:00:00Z","timestamp":1134086400000},"content-version":"vor","delay-in-days":10569,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[1977,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Twenty\u2010four patients with cancer and concomitant infections with either herpes virus hominis or varicella zoster virus were treated with polyinosinic\u00b7polycytidylic acid (rI<jats:sub>n<\/jats:sub>\u00b7rC<jats:sub>n<\/jats:sub>) to determine: (1) the reliability of rI<jats:sub>n<\/jats:sub>\u00b7rC<jats:sub>n<\/jats:sub> to induce interferon production, and (2) the toxicity of the drug. Seven additional patients with herpes zoster were observed as controls. Two lots of rI<jats:sub>n<\/jats:sub>\u00b7rC<jats:sub>n<\/jats:sub> were used; Lot 1 was consistently effective in stimulating serum interferon at doses of 9 and 12 mg\/kg, whereas Lot 2 was effective at doses of 3\u201312 mg\/kg. There was no correlation between rI<jats:sub>n<\/jats:sub>\u00b7rC<jats:sub>n<\/jats:sub> doses within these ranges and the resultant interferon levels. Generally, peak serum interferon occurred within the first day.<\/jats:p><jats:p>Toxicity to rI<jats:sub>n<\/jats:sub>\u00b7rC<jats:sub>n<\/jats:sub> consisted of fever in 21\/24 patients, mild elevation of liver enzymes in 8\/24 patients, and laboratory abnormalities of coagulation in 9 patients. The coagulation abnormalities appeared linearly related to the dose of rI<jats:sub>n<\/jats:sub>\u00b7rC<jats:sub>n<\/jats:sub> used. All these abnormalities were reversible, and none were considered severe or lifethreatening.<\/jats:p><jats:p>Sincer rI<jats:sub>n<\/jats:sub>\u00b7rC<jats:sub>n<\/jats:sub> was effective in stimulating interferon and since toxicity was considered acceptable, a randomized double\u2010blind study was initiated to determine whether rI<jats:sub>n<\/jats:sub>\u00b7rC<jats:sub>n<\/jats:sub> is effective in the treatment of herpes zoster.<\/jats:p>","DOI":"10.1002\/jmv.1890010202","type":"journal-article","created":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T07:14:07Z","timestamp":1172819647000},"page":"79-93","source":"Crossref","is-referenced-by-count":41,"title":["Pharmacologic effects of polyinosinic\u2022 polycytidylic acid in man"],"prefix":"10.1002","volume":"1","author":[{"given":"Arnold I.","family":"Freeman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nazar","family":"Al\u2010Bussam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith A.","family":"O'Malley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leon","family":"Stutzman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sigurdur","family":"Bjornsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William A.","family":"Carter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,12,9]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197011262832202"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(71)80281-0"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197503202921201"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196905292802201"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2836(72)90560-8"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.186.4170.1172"},{"key":"e_1_2_1_8_1","first-page":"440","article-title":"An integrated and comparative study ofthe antiviral effects and other biological properties of the rIn\u0159n duplex and its mismatched analogs: III. 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