{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T06:07:10Z","timestamp":1761718030250},"reference-count":15,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,12,7]],"date-time":"2005-12-07T00:00:00Z","timestamp":1133913600000},"content-version":"vor","delay-in-days":10202,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[1978,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Human cytomegalovirus (CMV), known to replicate in vitro in human fibroblastic cells, was found to replicate in epithelial human amnion (HA) cells. Large syncytia formed in these cells after infection with CMV; inclusion bodies were observed in the nuclei, and CMV antigens were demonstrated in both the cytoplasm and the nucleus by indirect immunofluorescence techniques. The synthesis of virus DNA was also detected, and the production of infectious virus was followed. The titers were lower (from 10<jats:sup>4<\/jats:sup> to 6 \u00d7 10<jats:sup>5<\/jats:sup> using different isolates of CMV) than those obtained in human embryo fibroblast (HEF) cells, and the replication cycle was slower in HA than in HEF cells.<\/jats:p>","DOI":"10.1002\/jmv.1890020410","type":"journal-article","created":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T08:14:59Z","timestamp":1172823299000},"page":"369-375","source":"Crossref","is-referenced-by-count":15,"title":["Infection of human amnion cells with cytomegalovirus"],"prefix":"10.1002","volume":"2","author":[{"given":"Manuel E.","family":"Figueroa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laszlo","family":"Geder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fred","family":"Rapp","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,7]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-92-22497"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-3955(16)31838-7"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197107222850406"},{"key":"e_1_2_1_5_2","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1128\/jvi.16.4.982-990.1975","article-title":"Long\u2010term persistence of ctomegalovirus genome in cultured human cells of prostatic origin","volume":"16","author":"Rapp F","year":"1975","journal-title":"Journal of Virolog"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.179143"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-92-22498"},{"key":"e_1_2_1_8_2","first-page":"2","volume-title":"Virolog Monographs","author":"Hanshaw JB","year":"1968"},{"key":"e_1_2_1_9_2","first-page":"473","article-title":"Ctopathogenicit of ctomegalovirus to human ecto\u2010 and endocervical epithelial cells in vitro","volume":"19","author":"Vesterinen E","year":"1975","journal-title":"Acta Ctologica"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1159\/000149933"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01318006"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01315617"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-94-22891"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-135-35031"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6822(76)90064-7"},{"key":"e_1_2_1_16_2","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1542\/peds.48.2.200","article-title":"Ctomegalovirus mononucleosis in a first trimester pregnant female with transmission to the fetus","volume":"48","author":"Davis LE","year":"1971","journal-title":"Pediatrics"}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjmv.1890020410","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.1890020410","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T00:11:31Z","timestamp":1699834291000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.1890020410"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1978,1]]},"references-count":15,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1978,1]]}},"alternative-id":["10.1002\/jmv.1890020410"],"URL":"https:\/\/doi.org\/10.1002\/jmv.1890020410","archive":["Portico"],"relation":{},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"value":"0146-6615","type":"print"},{"value":"1096-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[1978,1]]}}}