{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,30]],"date-time":"2023-09-30T09:42:21Z","timestamp":1696066941417},"reference-count":10,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,12,6]],"date-time":"2005-12-06T00:00:00Z","timestamp":1133827200000},"content-version":"vor","delay-in-days":9471,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[1980,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Newborn hamsters were inoculated intracerebrally (IC) with disrupted measles carrier Lu 106 cells. No acute neurological disease developed, but limited, persistent neural infection was identified by immune fluorescence and by virus isolation. By ten days after inoculation, virus could be recovered only by co cultivation of explant cultures of central nervous system (CNS) tissue and Vero cells. Virus was still demonstrable in CNS by both techniques 50 days after inoculation, the latest sample collected. Animals inoculated as newborns developed a poor hem agglutination\u2010inhibiting (HI) antibody response.<\/jats:p><jats:p>In three\u2010week\u2010old hamsters inoculated IC no detectable replication of carrier virus occurred. The serum HI antibody response was more than 20 times higher than that in animals inoculated as newborns.<\/jats:p><jats:p>Hydrocephalus developed in a fraction of animals inoculated at birth or at the age of three weeks. Both infectious and heat\u2010inactivated disrupted virus carrier material, but not control material of Lu 106 cells, gave hydrocephalus. The precise mechanism leading to hydrocephalus is unclear. Carrier virus material may produce a meningeal irritation causing disturbances of the extraventricular flow or resorption of cerebrospinal fluid, leading to communicating hydrocephalus. Infectious carrier virus may replicate in and destroy ependymal cells, further contributing to hydrocephalus.<\/jats:p>","DOI":"10.1002\/jmv.1890050203","type":"journal-article","created":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T09:36:25Z","timestamp":1172828185000},"page":"109-116","source":"Crossref","is-referenced-by-count":6,"title":["Further studies on subacute encephalitis and hydrocephalus in hamsters caused by measles virus from persistently infected cell cultures"],"prefix":"10.1002","volume":"5","author":[{"given":"Erling","family":"Norrby","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peggy","family":"Swoveland","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth P.","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krister","family":"Kristensson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,6]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/126.1.18"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.76.4.2047"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4800(74)90087-2"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1977.00500130038008"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-65297-4_1"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-111-27930"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01241275"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.1890020404"},{"key":"e_1_2_1_10_1","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.4049\/jimmunol.107.6.1593","article-title":"Latent measles virus infection of the hamster central nervous system","volume":"107","author":"Wear DJ","year":"1971","journal-title":"Journal of Immunology"},{"issue":"23","key":"e_1_2_1_11_1","doi-asserted-by":"crossref","first-page":"884","DOI":"10.4049\/jimmunol.123.2.884","article-title":"Immune response in subacute sclerosing panencephalitis: Reduced antibody response to the matrix protein of measles virus","volume":"1","author":"Wechsler SL","year":"1979","journal-title":"Journal of Immunology"}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjmv.1890050203","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.1890050203","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T12:30:19Z","timestamp":1695990619000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.1890050203"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1980,1]]},"references-count":10,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1980,1]]}},"alternative-id":["10.1002\/jmv.1890050203"],"URL":"https:\/\/doi.org\/10.1002\/jmv.1890050203","archive":["Portico"],"relation":{},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"value":"0146-6615","type":"print"},{"value":"1096-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[1980,1]]}}}